ORIGINAL ARTICLE

Diagnostics of early dysfunctions of anticoagulant and fibrinolytic features of rats’ vessels in the course of metabolic syndrome formation with the help of fructose model

Boris Veniaminovich Usha , Svetlana Yurevna Zavalishina, Yuri Anatolyevich Vatnikov, Evgeniy Vladimirovich Kulikov, Vladimir Ivanovich Kuznetsov, Nikolay Vladimirovich Sturov, Margarita Vasilievna Kochneva, Anton Alexandrovich Poddubsky, Alina Vadimovna Petryaeva, Tatyana Ivanovna Glagoleva

Boris Veniaminovich Usha
Moscow state University of food production, Volokolamskoe Highway 11, Moscow, 125080, Russian Federation. Email: ushabv@gmail.com

Svetlana Yurevna Zavalishina
Kursk Institute of Social Education (branch of the institute RSSU [Russian State Social University]), 53 K.Marx st., Kursk, 305029, Russian Federation All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals, Institute of village, Institut village, Borovsk, 249013, Russian Federation

Yuri Anatolyevich Vatnikov
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Evgeniy Vladimirovich Kulikov
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Vladimir Ivanovich Kuznetsov
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Nikolay Vladimirovich Sturov
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Margarita Vasilievna Kochneva
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Anton Alexandrovich Poddubsky
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Alina Vadimovna Petryaeva
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation

Tatyana Ivanovna Glagoleva
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals, Institute of village, Borovsk, Russian Federation
Online First: December 20, 2018 | Cite this Article
Usha, B., Zavalishina, S., Vatnikov, Y., Kulikov, E., Kuznetsov, V., Sturov, N., Kochneva, M., Poddubsky, A., Petryaeva, A., Glagoleva, T. 2018. Diagnostics of early dysfunctions of anticoagulant and fibrinolytic features of rats’ vessels in the course of metabolic syndrome formation with the help of fructose model. Bali Medical Journal 8(1): 201-205. DOI:10.15562/bmj.v8i1.923


The optimal feature of anticoagulant and fibrinolytic of the vascular wall provides the major homeostasis process in the whole body of a mammal. It is impossible to track in clinic peculiarities of the earliest change in vascular hemostasis in a debut of metabolic syndrome formation. Thus, it dictates the necessity of conducting experimental researches on laboratory animals with modeling of metabolic syndrome within them. The aim of the research is to examine early stages of vascular hemocoagulation weakening control in conditions such as the formation of metabolic syndrome. The study used 61 male-rats of Wister line at the age of 2.5-3 months. The animals were subdivided into two groups: 32 rats received 10% fructose dilution with free access for drinking, and 29 rats to the control group.  Biochemical, hematological and statistical methods of investigation were applied. We found that in high fructose level, there is a fast evident of a weakening of the anticoagulant and fibrinolytic activities of vascular endothelium as well as the body mass gain and development of biochemical abnormalities, which is typical for metabolic syndrome. The early weakening of vascular control over hemocoagulation turns metabolic syndrome into a very dangerous state because of thromboses, which may take place even at the very beginning of its development.

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