Ganglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness

Andi Pratiwi Machmud; Andi Muhammad Ichsan; Habibah Setyawati Muhiddin

doi:10.15562/bmj.v7i2.861

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Ganglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness

Andi Pratiwi Machmud ,

Andi Muhammad Ichsan ,

Habibah Setyawati Muhiddin ,

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DOI: https://doi.org/10.15562/bmj.v7i2.861 |
Published: 2018-08-01

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Abstract

Purpose : To compare the Ganglion Cell Complex (GCC) thickness with Retinal Nerve Fiber Layer
(RNFL) thickness in correlation with visual field (VF) in varying degrees of myopia. Design: a Cross-
Sectional study. Participants: Ninety-six eyes of 49 patients with myopia. Methods: Patients with
myopia examined with streak retinoscope to obtained the best corrected visual acuity based on
spherical equivalent. Patients then divided into low (50 eyes=50.1%), moderate (31 eyes=32.3%), and
high (15=15.6%) myopia. Axial length measured with A-Scan ultrasound divided into short (4=4.2%),
moderate (74=77.1%), and long (18=18.7%). SD-OCT was used to measured GCC thickness in 9 areas
including fovea (R1), parafovea (R2-R5), and perifovea (R6-R9) according to early treatment diabetic
retinopathy study (ETDRS), and RNFL thickness in five areas (G, TS, TI, NS, N, NI). VF analysis
with humphrey field analyzer with SITA 24-2 pattern. Main outcome measures: GCC thickness has
higher correlation with degree of myopia particularly in perifovea area and means deviation than
RNFL thickness. Results: GCC thickness decreased significantly along with the elevation of myopia
degree in almost entire area except R1 and R5 . Parafovea (R2-R4) and perifovea (R6-R9) were
significantly correlated with p= 0.001, 0.005, 0.006 and p= 0.000, 0.000, 0.000, and 0.003
respectively. In contrast, RNFL thickness obtained lower correlation with myopia degree whereas the
only significant result was found in Nasal area (p= 0.045). VF found to be strongly correlated with the
degree of myopia in which p-value for Mean Deviation = 0.000. Conclusions: GCC thickness may
compare the predictive value of RNFL in predicting early retinal microstructural changes even in low
degree myopia. Financial Disclosure: Author has no financial disclosure.

Keywords: Medicine

How to Cite

Machmud, A. P., Ichsan, A. M., & Muhiddin, H. S. (2018). Ganglion Cell Complex thickness as an early predictor of microstructural changes in varying degrees of myopia in comparison with Retinal Nerve Fiber Layer (RNFL) thickness. Bali Medical Journal, 7(2), 1–5. https://doi.org/10.15562/bmj.v7i2.861