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Immunohistochemical examination of recurrence and giant cell tumor specificity, is it correlated? cohort retrospective study


Link of Video Abstract:


Introduction: GCT is a benign tumor that has an aggressive local character. GCT recurrence after disinfection still often occurs. The reasons for treatment failure and triggering a recurrence are believed to be the role of the accumulation of stem cells in promoting tumor initiation and recurrence.

Methods: Study Cohort Retrospective cohort in patients who had undergone surgery with a diagnosis of GCT at RSUPN Dr. Cipto Mangunkusumo in 2017-2022. The subjects were separated into two groups, recurrence patients and non-recurrence patients. The tissue biopsy will be assessed with ALCAM+, Oct4, and Stro-1 biomarkers for tumor stem cells.

Results: A total of 38 patients were diagnosed with Giant Cell Tumor. There were 31.6% of recurrent patients with an age range between 31-40 years and 41-50 years. The most common location is the Distal Radius with a score of 41.7% in recurrent patients and 38.5% in non-recurrent patients. Based on the data, the expression of ALCAM+, OCT4 and Stro-1 did not have significant differences between the two groups. The Recurrence group in p63 was expressed more than in the Non-Recurrence group p=0.002. In CD147, the Recurrence group was also expressed more than in the Non-Recurrence group p=0.003

Conclusion: Increased expression of ALCAM+, OCT4, and Stro-1 occurred in Recurrence and Non-Recurrence patients, although Stro-1 appeared to be more sensitive in detecting GCT progression, but was not statistically different. CD147 and p63 are statistically different between recurrence and non-recurrence.


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How to Cite

Surachman, A. J. D. ., Kamal, A. F. ., Septelia, I. W. ., Siregar, N. C. ., Rahyussalim, Alida, R. H. ., & Dewi, S. S. . (2023). Immunohistochemical examination of recurrence and giant cell tumor specificity, is it correlated? cohort retrospective study. Bali Medical Journal, 13(1), 322–326.




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Achmad Jadi Didy Surachman
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Achmad Fauzi Kamal
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Inawati Wanandi Septelia
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Nurjati Chairani Siregar
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Roswita Harahap Alida
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