Skip to main content Skip to main navigation menu Skip to site footer

Supplementation of vitamin D reduces energy intake and prevents body fatness accumulation in obese woman

  • Linda Sinto ,
  • I Wayan Weta ,
  • Komang Bagus Satriasa ,
  • Nyoman Mantik Astawa ,


Link of Video Abstract:


Introduction: Obese people are at higher risk of comorbidities, including metabolic syndrome, autoimmune, tumor progression and other inflammation diseases because of low-grade chronic inflammation. Vitamin D is closely related to transcriptional activity in adipose tissue, which regulates adipogenesis, inflammatory pathways, and adipose cell metabolism. This research aims to know the effect of Vitamin D supplementation on energy intake and body fat accumulation.

Methods: 40 obese women between the ages of 26 and 45 were randomly assigned to the Intervention and Control groups, which received daily supplements of 5000 IU of vitamin D and a placebo, respectively. Data were gathered before the intervention and after 12 weeks of it. We measured the energy intake, BMI, waist circumference (WC), and conicity index. The participants were told to keep their daily calorie consumption at or below 1500 kcal.

Results: After 12 weeks of supplementation, 25(OH) Vitamin D levels increased significantly (p=0.001), and energy intake decreased (p=0.014) significantly in the intervention group, but no change in the control group (p>0,05). Body fatness indices (BMI and WC) increased (p=0.005 and p=0.003) significantly in the control group; however, these parameters did not change in the intervention group (p>0.05).

Conclusion: Daily Vitamin D 5000 IU for 12 weeks decreases energy intake and prevents body fat accumulation in obese women.


  1. Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity & inflammation: The linking mechanism & the complications. Arch Med Sci. 2017;13(4). doi: 10.5114/aoms.2016.58928
  2. Elieh Ali Komi D, Shafaghat F, Christian M. Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions. Vol. 58, Clinical Reviews in Allergy and Immunology. 2020. doi: 10.1007/s12016-020-08785-7
  3. Miao Z, Wang S, Wang Y, Guo L, Zhang J, Liu Y, et al. A Potential Linking between Vitamin D and Adipose Metabolic Disorders. Vol. 2020, Canadian Journal of Gastroenterology and Hepatology. 2020. doi: 10.1155/2020/2656321
  4. Daryabor G, Kabelitz D, Kalantar K. An update on immune dysregulation in obesity-related insulin resistance. Vol. 89, Scandinavian Journal of Immunology. 2019. doi: 10.1111/sji.12747
  5. Morin SO, Poggi M, Alessi MC, Landrier JF, Nunès JA. Modulation of T Cell Activation in Obesity. Vol. 26, Antioxidants and Redox Signaling. 2017. doi: 10.1089/ars.2016.6746
  6. Zakharova I, Klimov L, Kuryaninova V, Nikitina I, Malyavskaya S, Dolbnya S, et al. Vitamin D insufficiency in overweight and obese children and adolescents. Vol. 10, Frontiers in Endocrinology. 2019. doi: 10.3389/fendo.2019.00103
  7. Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. Vol. 222, Journal of Endocrinology. 2014. doi: 10.1530/JOE-14-0283
  8. Chen X, Wu W, Wang L, Shi Y, Shen F, Gu X, et al. Association between 25-Hydroxyvitamin D and epicardial adipose tissue in Chinese non-obese patients with type 2 diabetes. Med Sci Monit. 2017;23. doi: 10.12659/MSM.904755
  9. Seldrup J, Pocock SJ. Clinical Trials. A Practical Approach. Stat. 1985;34(3). doi: 10.2307/2987660
  10. Webb AR, Kazantzidis A, Kift RC, Farrar MD, Wilkinson J, Rhodes LE. Colour counts: Sunlight and skin type as drivers of vitamin D deficiency at UK latitudes. Nutrients. 2018;10(4). doi: 10.3390/nu10040457
  11. Szymczak-Pajor I, Miazek K, Selmi A, Balcerczyk A, Śliwińska A. The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders? Vol. 23, International Journal of Molecular Sciences. 2022. doi: 10.3390/ijms23020956
  12. Indra TA, Lydia A, Purnamasari D, Setiati S. Asosiasi antara Status Vitamin D 25(Oh)D dengan Albuminuria pada Pasien Diabetes Melitus Tipe 2. J Penyakit Dalam Indones. 2017;4(1). doi: 10.7454/jpdi.v4i1.108
  13. Codoñer-Franch P, Tavárez-Alonso S, Simó-Jordá R, Laporta-Martín P, Carratalá-Calvo A, Alonso-Iglesias E. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. J Pediatr. 2012;161(5). doi: 10.1016/j.jpeds.2012.04.046
  14. Lin E, Armstrong-Moore D, Liang Z, Sweeney JF, Torres WE, Ziegler TR, et al. Contribution of adipose tissue to plasma 25-hydroxyvitamin D concentrations during weight loss following gastric bypass surgery. Obesity. 2011;19(3). doi: 10.1038/oby.2010.239
  15. Vaes AMM, Tieland M, de Regt MF, Wittwer J, van Loon LJC, de Groot LCPGM. Dose–response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults. Clin Nutr. 2018;37(3). doi: 10.1016/j.clnu.2017.03.029
  16. Vranić L, Mikolašević I, Milić S. Vitamin D deficiency: Consequence or cause of obesity? Vol. 55, Medicina (Lithuania). 2019. doi: 10.3390/medicina55090541
  17. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Med. 2013;10(2). doi: 10.1371/journal.pmed.1001383
  18. Magge SN, Prasad D, Zemel BS, Kelly A. Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents. J Clin Transl Endocrinol. 2018;12. doi: 10.1016/j.jcte.2018.03.001
  19. Bassatne A, Chakhtoura M, Saad R, Fuleihan GEH. Vitamin D supplementation in obesity and during weight loss: A review of randomized controlled trials. Vol. 92, Metabolism: Clinical and Experimental. 2019. doi: 10.1016/j.metabol.2018.12.010
  20. Kong J, Chen Y, Zhu G, Zhao Q, Li YC. 1,25-Dihydroxyvitamin D3 upregulates leptin expression in mouse adipose tissue. J Endocrinol. 2013;216(2). doi: 10.1530/JOE-12-0344
  21. Madhu S V., Aslam M, Mishra BK, Gupta A, Jhamb R. Association of 25 (OH) Vitamin D and leptin in individuals with insulin resistance. Indian J Endocrinol Metab. 2022;26(5). doi: 10.4103/ijem.ijem_141_22
  22. Maetani M, Maskarinec G, Franke AA, Cooney R V. Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women. Nutr Cancer. 2009;61(2). doi: 10.1080/01635580802455149
  23. Kelishadi R, Roufarshbaf M, Soheili S, Payghambarzadeh F, Masjedi M. Association of Childhood Obesity and the Immune System: A Systematic Review of Reviews. Vol. 13, Childhood Obesity. 2017. doi: 10.1089/chi.2016.0176
  24. Abboud M, Liu X, Fayet-Moore F, Brock KE, Papandreou D, Brennan-Speranza TC, et al. Effects of vitamin D status and supplements on anthropometric and biochemical indices in a clinical setting: A retrospective study. Nutrients. 2019;11(12). doi: 10.3390/nu11123032
  25. Dewantiningrum J, Hartanto F, Mexitalia M, Soejoenoes A, Ediati A, Hadisaputro S, et al. Brain-derived neurotrophic factor (BDNF) and the capute scales in offspring of mothers with normal and deficient vitamin D levels. Bali Med J. 2023;12(1). doi: 10.15562/bmj.v12i1.3711
  26. Vanlint S. Vitamin D and obesity. Nutrients. 2013; 20;5(3):949-56. doi: 10.3390/nu5030949

How to Cite

Sinto, L., I Wayan Weta, Komang Bagus Satriasa, & Nyoman Mantik Astawa. (2023). Supplementation of vitamin D reduces energy intake and prevents body fatness accumulation in obese woman. Bali Medical Journal, 12(3), 3093–3097.




Search Panel