Skip to main content Skip to main navigation menu Skip to site footer

Effect of Asiatic acid and dexamethasone administration to interleukin (IL)-1 expression and number of mononuclear cells in extraocular muscle post-strabismus surgery

  • Intifada ,
  • Luki Indriaswati ,
  • Dicky Hermawan ,


Abstract

Strabismus surgery aims to improve visual function, binocular vision, and cosmetics by fixing the position of the eyeball. However, inflammation after surgery can lead to fibrous tissue formation. Dexamethasone is routinely used as an anti-inflammatory but has unwanted side effects. On the other hand, Asiatic acid, the most important saponin constituent of Centella asiatica, has anti-inflammatory and anti-fibrous properties. It has been widely used as a traditional medicine plant in China, India, and Indonesia. The findings show that Asiatic acid has been shown to affect wound healing after strabismus surgery positively. Asiatic acid inhibits inflammation, increases cell proliferation, and inhibits fibrosis. It promotes wound healing by increasing the strength of the incision wound, epithelialization, keratinization, and angiogenesis. Overall, using natural compounds like Asiatic acid in wound healing is promising and should be explored further. It can be a safer and more effective alternative to dexamethasone, which has known side effects. However, further studies are required to determine the optimal dosage and administration method of Asiatic acid for post-operative strabismus wound healing. The results of this study are expected to be the basis for selecting alternative therapies to reduce inflammation and fibrosis after strabismus surgery.

Keywords: Asiatic acid dexamethasone inflammation strabismus surgery wound healing

References

  1. Huang W, Gao F, Hu F, Huang J, Wang M, Xu P, et al. Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in A Rat Model of Glaucoma. Front Neurosci. 2018 Jul 20;12(JUL).
  2. Lv J, Sharma A, Zhang T, Wu Y, Ding X. Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound. SLAS Technol. 2018 Apr 1;23(2):111–27.
  3. Adtani PN, Narasimhan M, Punnoose AM, Kambalachenu HR. Antifibrotic Effect of Centella asiatica Linn and Asiatic Acid on Arecoline-induced Fibrosis in Human Buccal Fibroblasts. J Investig Clin Dent. 2017 May 1;8(2).
  4. Bani AP, Putera I, Susanto E, La Distia Nora R. Comparative Assessment of Short-Term Tendon-Scleral Postoperative Inflammation and α-Smooth Muscle Actin Expression following Oral and Topical Diclofenac Administration for Strabismus Surgery in Rabbits. Curr Eye Res. 2022 Dec 13;1–8.
  5. Bian D, Zhang J, Wu X, Dou Y, Yang Y, Tan Q, et al. Asiatic Acid Isolated From Centella asiatica Inhibits TGF-β1-Induced Collagen Expression in Human Keloid Fibroblasts via PPAR-γ Activation. Int J Biol Sci. 2013 Oct 25;9(10):1032–42.
  6. Dong SH, Liu YW, Wei F, Tan HZ, Han ZD. Asiatic Acid Ameliorates Pulmonary Fibrosis Induced by Bleomycin (BLM) via Suppressing Pro-fibrotic and Inflammatory Signaling Pathways. Biomedicine and Pharmacotherapy. 2017 May 1;89:1297–309.
  7. Tang L xia, He R hua, Yang G, Tan J ju, Zhou L, Meng X ming, et al. Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-Beta/Smad Signaling In Vivo and In Vitro. PLoS One. 2012 Feb 7;7(2).
  8. Ludwig IH, Chow AY. Scar Remodeling After Strabismus Surgery. Journal of AAPOS. 2000;4(6):326–33.
  9. National Center for Biotechnology Information. Dexamethasone. PubChem Compound Summary for CID 5743 [Internet]. 2022 [cited 2022 Jan 4]; Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Dexamethasone
  10. Han KE, Baek SH, Kim SH, Lim KH. Prevalence and Risk Factors of Strabismus in Children and Adolescents in South Korea: Korea National Health and Nutrition Examination Survey, 2008 ± 2011. PLoS One. 2018 Feb 1;13(2).
  11. Wright KW, Hong P. Strabismus Surgery. In: Handbook of Pediatric Strabismus and Amblyopia. New York: Springer; 2016. p. 388–422.
  12. Zhang XJ, Lau YH, Wang YM, Kam KW, Ip P, Yip WW, et al. Prevalence of Strabismus and Its Risk Factors Among School Aged Children: The Hong Kong Children Eye Study. Sci Rep. 2021 Dec 1;11(1).
  13. Almahmoudi FH, Al Shamrani M, Khan AM. The Use of One Muscle Recession for Horizontal Strabismus. Saudi Journal of Ophthalmology. 2018 Jul 1;32(3):200–3.
  14. Hopker LM, Weakley DR. Surgical Results After One-Muscle Recession for Correction of Horizontal Sensory Strabismus in Children. Journal of AAPOS. 2013 Apr;17(2):174–6.
  15. Paduca A, Arnaut O, Bendelic E, Bruenech JR, Lundmark PO. Extraocular Muscle Resection, Recession Length and Surgery Outcome Modelling in Strabismus Treatment: A Pilot Study. BMJ Open Ophthalmol. 2021 Nov 5;6(1).
  16. Demirel S, Atilla H, Heper AO, Erkam N. Effects of Amniotic Membrane on Wound Healing and Adhesions in Experimental Strabismus Surgery. Eur J Ophthalmol. 2009;19(6):899–904.
  17. Choi HY, Lee JH, Lee JE, Jung JH. Effect of Bevacizumab on Strabismus Surgery in Rabbits. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4585–8.
  18. Choi SU, Kim KW, Moon NJ. Effective Treatment for Prevention of Post-Operative Adhesion After Strabismus Surgery in Experimental Rabbit Model: 0.5% Tranilast Ophthalmic Solution. BMC Ophthalmol. 2016 Sep 21;16(1).
  19. Indriaswati L, Suhendro G, Handajani R. Time-dependent Expression of Caspase-3 and Degeneration of Lateral Rectus Muscle on Experimental Esotropia in Rabbits. Indian Journal of Forensic Medicine & Toxicology. 2021;15(2).
  20. Than UTT, Guanzon D, Leavesley D, Parker T. Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing. Int J Mol Sci. 2017 May 1;18(5).
  21. Cañedo-Dorantes L, Cañedo-Ayala M. Skin Acute Wound Healing: A Comprehensive Review. Int J Inflam. 2019;2019.
  22. Gonzalez ACDO, Andrade ZDA, Costa TF, Medrado ARAP. Wound Healing - A Literature Review. An Bras Dermatol. 2016 Sep 1;91(5):614–20.
  23. Lin HC, Lee HS, Chiueh TS, Lin YC, Lin HA, Lin YC, et al. Histopathological Assessment of Inflammation and Expression of Inflammatory Markers in Patients with Ketamine-induced Cystitis. Mol Med Rep. 2015 Apr 1;11(4):2421–8.
  24. Velnar T, Bailey T, Smrkolj V. The Wound Healing Process: an Overview of the Cellular and Molecular Mechanisms. J Int Med Res. 2009;37(5):1528.
  25. Ghazi NG, Green WR. Pathology and Pathogenesis of Retinal Detachment. Eye. 2002;16(4):411–21.
  26. Kleiveland CR. Peripheral Blood Mononuclear Cells. In: The Impact of Food Bioactives on Health. Cham: Springer International Publishing; 2015. p. 161–7.
  27. Meeran MFN, Goyal SN, Suchal K, Sharma C, Patil CR, Ojha SK. Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise. Front Pharmacol. 2018 Sep 4;9(SEP).
  28. Chen H, Hua XM, Ze BC, Wang B, Wei L. The Anti-inflammatory Effects of Asiatic acid in Lipopolysaccharide-stimulated Human Corneal Epithelial Cells. Int J Ophthalmol. 2017 Feb 18;10(2):179–85.
  29. Fan Y, Yin X. Potential Therapeutic Targets and Biological Mechanisms of Centella asiatica on Hepatic Fibrosis: A Study of Network Pharmacology. Ann Transl Med. 2021 Jun;9(11):932–932.
  30. Meng X ming, Zhang Y, Huang XR, Ren G ling, Li J, Yao Lan H. Treatment of Renal Fibrosis by Rebalancing TGF-β/Smad Signaling With the Combination of Asiatic Acid and Naringenin. Oncotarget [Internet]. 2015;6(35). Available from: www.impactjournals.com/oncotarget
  31. Zhang YW, Tu LL, Zhang Y, Pan JC, Zheng GL, Yin LN. Liver-Targeted Delivery of Asiatic acid Nanostructured Lipid Carrier for the Treatment of Liver Fibrosis. Drug Deliv. 2021;28(1):2534–47.
  32. Kaneko N, Kurata M, Yamamoto T, Morikawa S, Masumoto J. The Role of Interleukin-1 in General Pathology. Inflamm Regen. 2019 Jun 6;39(1).
  33. Durmus M, Karaaslan E, Ozturk E, Gulec M, Iraz M, Edali N, et al. The Effects of Single-Dose Dexamethasone on Wound Healing in Rats. Anesth Analg. 2003;97(5):1377–80.
  34. Hübner G, Brauchle M, Smola H, Madlener M, Fässler R, Werner S. Differential Regulation of Pro-Inflammatory Cytokines During Wound Healing in Normal and Glucocorticoid-Treated Mice. Cytokine. 1996;8(7):548–56.
  35. Kern JA, Lamb RJ, Reed JC, Daniele RP, Nowell PC. Dexamethasone Inhibition of Interleukin 1 Beta Production by Human Monocytes Posttranscriptional Mechanisms. J Clin Invest. 1988;
  36. Kylm’aniemil M, Oikarinen2 A, Oikarinen3 K, Salo3 T. Effects of Dexamethasone and Cell Proliferation on the Expression of Matrix Metalloproteinases in Human Mucosal Normal and Malignant Cells. J Dent Res. 1996;75(3):919–26.
  37. Lu Y, Fukuda K, Liu Y, Kumagai N, Nishida T. Dexamethasone Inhibition of IL-1-Induced Collagen Degradation by Corneal Fibroblasts in Three-Dimensional Culture. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):2998–3004.
  38. Luo JC, Cho CH, Ng KM, Hsiang KW, Lu CL, Che TS, et al. Dexamethasone Inhibits Tumor Necrosis Factor-a-stimulated Gastric Epithelial Cell Migration. J Chin Med Assoc. 2009;72(10):509–14.
  39. Meisler N, Keefer KA, Ehrlich HP, Yager DR, Myers-Parrelli J, Cutroneo KR. Dexamethasone Abrogates the Fibrogenic Effect of Transforming Growth Factor-β in Rat Granuloma and Granulation Tissue Fibroblasts.
  40. Journal of Investigative Dermatology. 1997;108(3):285–9. Parwanto E, Wratsangka R, Guyansyah A, Anggraeni K,
  41. Digambiro RA, Tjahyadi D, Arkeman H, Widyatama HG, Edy HJ, Edy YJ. The change of cell biometric and its nucleus on cervical-squamous-epithelial-cell with GA genotype of Fas-promoter-670 gene, high-risk human papillomavirus and Candida species infection: a case report. Bali Med J. [Internet]. 2021 Apr. 1 [cited 2023 Jul. 13];10(1):74-81. Available from: https://www.balimedicaljournal.org/index.php/bmj/article/view/2138.
  42. Suastika LOS, Oktaviono YH, Soemantri D, Sandra F. Purple sweet potato extract and vitamin C increase the proliferation of endothelial progenitor cells from stable coronary artery disease patients. Bali Med J. [Internet]. 2021 Apr. 30 [cited 2023 Jul. 13];10(1):243-8. Available from: https://www.balimedicaljournal.org/index.php/bmj/article/view/2261
  43. Airlangga MS, Prastyani R, Nurwasis, Plumeriastuti H, Utomo B. The effectiveness of platelet rich fibrin (PRF) graft to expression of IL-1 and TNF-α in cornea post NaOH exposure: an experimental study. Bali Med J. [Internet]. 2023 Apr. 28 [cited 2023 Jul. 13];12(2):1347-52. Available from: https://www.balimedicaljournal.org/index.php/bmj/article/view/4389

How to Cite

Intifada, Indriaswati, L. ., & Hermawan, D. . (2023). Effect of Asiatic acid and dexamethasone administration to interleukin (IL)-1 expression and number of mononuclear cells in extraocular muscle post-strabismus surgery. Bali Medical Journal, 12(2), 2258–2263. https://doi.org/10.15562/bmj.v12i2.4644
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
3

Total
2

Share

Search Panel

Intifada
Google Scholar
Pubmed
BMJ Journal

Luki Indriaswati
Google Scholar
Pubmed
BMJ Journal

Dicky Hermawan
Google Scholar
Pubmed
BMJ Journal