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Identification of tumor infiltrating lymphocyte CD8 in Indonesian colorectal cancer population: a cross-sectional study

  • Elit Irawan ,
  • Kiki Lukman ,
  • Nurhayat Usman ,
  • Bambang Am Am Setya Sulthana ,
  • Reno Rudiman ,
  • Deny Budiman ,
  • Prapanca Nugraha ,
  • Etis Primastari ,


Abstract

Link of Video Abstract: https://youtu.be/KymCxU8ATU0

 

Background: Colorectal cancer is now the third most common cancer both globally and in Indonesia. An important component of the adaptive immune system, tumor-infiltrating lymphocytes (TILs) cluster of differentiation 8 (CD8+) are key in the immune response to malignancies, which were previously believed to be the primary initiators of anti-tumor immunity. A higher TIL CD8+ levels in the tumor microenvironment and a better prognosis have been associated with anticancer benefits in a number of cancers. This study aimed to describe the characteristics of colorectal cancer patients with increased tumor-infiltrating lymphocyte CD8+ expression and their relationship with clinicopathological features.

Methods: A cross-sectional investigation was conducted. Patients in the digestive surgery division with colorectal cancer served as the study's research subjects. There were 36 study subjects that were randomly selected from the available specimens. Examination of tumor-infiltrating lymphocytes CD8+ expression was carried out by the immunohistochemistry method.

Result: Expression of tumor-infiltrating lymphocytes CD8+, was positive in nine (25%) patients, and normal expression was shown in 27 (75%) patients. Most of the patients had adenocarcinomas histologically (91.7%), and 66.7% of patients were older than 50, with 77.8% of the tumors located at the rectum. Univariate analysis of the clinicopathological characteristics related to the tumor-infiltrating lymphocytes CD8+, showed a non-significant relationship statistically (p > 0.05).

Conclusion: There was no relationship between clinicopathological characteristics and tumor-infiltrating lymphocyte CD8+ expression in colorectal cancers.

Keywords: Colorectal Cancer immunohistochemistry infiltrating lymphocyte tumor-infiltrating lymphocyte

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How to Cite

Irawan, E., Lukman, K., Usman, N., Sulthana, B. A. A. S., Rudiman, R., Budiman, D., Nugraha, P., & Primastari, E. (2023). Identification of tumor infiltrating lymphocyte CD8 in Indonesian colorectal cancer population: a cross-sectional study. Bali Medical Journal, 12(2), 1781–1785. https://doi.org/10.15562/bmj.v12i2.4520
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