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Body mass index and total testosterone level in obese male pre-diabetic patients: correlation with homeostasis model assessment of insulin resistance

  • Eva Decroli ,
  • Dinda Aprilia ,
  • Alexander Kam ,
  • Afdol Rahmadi ,

Abstract

Link of Video Abstract: https://www.youtube.com/watch?v=zABLxwmAXtA

 

Introduction: Men with comorbidities are typically more likely to have testosterone insufficiency. In this study, total testosterone levels in obese male pre-diabetic patients will be correlated with body mass index and a homeostasis model assessment of insulin resistance (HOMA-IR).

Methods: This investigation is a cross-sectional analytical observational study. Insulin resistance was measured by HOMA-IR. Enzyme link immunosorbent assay (ELISA) was used to measure the total testosterone levels. 35 obese male patients who were also pre-diabetic had these signs evaluated.

Results: In this study, 35 obese male individuals with a family history of type 2 diabetes mellitus and an average age of 31.91 were included (3.79). The total testosterone level was 328.72 (94.94), the mean BMI was 33.12 (4.11) kg/m2, the HOMA-IR was 3.64 (1.00), and testosterone levels were lowered (300 ng/dl) in 48% of the individuals. In male pre-diabetic individuals, there was a strong negative connection between BMI and Total Testosterone levels (r = -0.567, p=0.001). In male pre-diabetic patients, there was a significant negative connection between HOMA-IR and total testosterone levels (r = -0.671, p=0.001).

Conclusion: In pre-diabetic obese male patients, there was a strong inverse relationship between total testosterone level and BMI. In obese male pre-diabetic individuals, there is a substantial negative association between HOMA-IR and total testosterone level.

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How to Cite

Decroli, E. ., Aprilia, D., Kam, A., & Rahmadi, A. (2024). Body mass index and total testosterone level in obese male pre-diabetic patients: correlation with homeostasis model assessment of insulin resistance. Bali Medical Journal, 13(1), 427–430. https://doi.org/10.15562/bmj.v13i1.4190

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