Skip to main content Skip to main navigation menu Skip to site footer

Effect of arabica Gayo coffee skin in repairing collagen damaged by UVB exposure

  • Wahyu Lestari ,
  • Sitti Hajar ,
  • Nanda Earlia ,
  • Cynthia Wahyu Asrizal ,
  • Muhammad Arif Ritonga ,


Abstract

Introduction: Skin aging can be accelerated by UV exposure from the sun. UV exposure will increase oxidative stress to disturb collagen synthesis. To overcome the increase of oxidative stress, antioxidant compound from plants, such as coffee cascara pulp, can be utilized. Previous research proves that coffee cascara has the potential to overcome photoaging due to its content. This research aims to assess the benefits of topical cascara pulp arabica coffee extract cream on the number of collagen fibers thickness and density of Wistar rats (Rattus norvegicus) as a treatment for photoaging.

Method: 30 male Wistar rats (Rattus norvegicus) was divided to 5 groups. The negative control group (PN) was given base cream and the positive control (PP) was given vitamin C 3%. The treatment group was given cascara pulp arabica coffee extract cream with 5% concentration (P1), 7.5 concentration (P2), and 10% concentration (P3). The group was exposed to 840 mJ/cm2 of UVB in total for 4 weeks. Skin biopsy was done to assess the thickness and density of collagen fiber through histological examination using masson trichrome staining.

Result: The result shows significant differences (p<0.05) in collagen fiber thickness and density between the control and treatment groups. The topical application of cascara pulp arabica coffee extract cream gives higher collagen fiber density and thickness.

Conclusion: Applying cascara pulp arabica coffee extract cream can protect and repair dermal collagen of male wistar rats (Rattus norvegicus) exposed to UVB.

Keywords: Photoaging cascara pulp Gayo arabica coffee extract cream skin collagen UVB

References

  1. Halder RM, Ara CJ. Skin cancer and photoaging in ethnic skin. Dermatol Clin. 2003;21(4):725–32. Available from: http://dx.doi.org/10.1016/s0733-8635(03)00085-8
  2. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules. 2015;5(2):545–89. Available from: https://pubmed.ncbi.nlm.nih.gov/25906193
  3. Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al. Fitzpatrick’s Dermatology in General Medicine. 9th ed. New York: McGraw-Hill Education LLC; 2019.
  4. Yaar M. Clinical and Histological Features of Intrinsic versus Extrinsic Skin Aging [Internet]. Skin Aging. Springer-Verlag; p. 9–21. Available from: http://dx.doi.org/10.1007/3-540-32953-6_2
  5. Petruk G, Del Giudice R, Rigano MM, Monti DM. Antioxidants from Plants Protect against Skin Photoaging. Oxid Med Cell Longev. 2018;2018:1454936. Available from: https://pubmed.ncbi.nlm.nih.gov/30174780
  6. Muharam F, Sriwidodo. REVIEW : The Potential of Arabica Coffee (Coffea Arabica L.) From Various Pharmacological &Amp; Pharmaceutical Dosage Forms. Med Sains J Ilm Kefarmasian. 2022;7(3):395–406. Available from: http://dx.doi.org/10.37874/ms.v7i3.349
  7. Zainura U, Kusnadi N, Burhanuddin B. Perilaku Kewirausahaan Petani Kopi Arabika Gayo di Kabupaten Bener Meriah Provinsi Aceh. J Penyul. 2016;12(2):126. Available from: http://dx.doi.org/10.25015/penyuluhan.v12i2.11606
  8. Islam MT, Tabrez S, Jabir NR, Ali M, Kamal MA, da Silva Araujo L, et al. An Insight into the Therapeutic Potential of Major Coffee Components. Curr Drug Metab. 2018;19(6):544–56. Available from: http://dx.doi.org/10.2174/1389200219666180302154551
  9. Esquivel P, Jiménez VM. Functional properties of coffee and coffee by-products. Food Res Int. 2012;46(2):488–95. Available from: http://dx.doi.org/10.1016/j.foodres.2011.05.028
  10. Iriondo-DeHond A, Elizondo AS, Iriondo-DeHond M, Ríos MB, Mufari R, Mendiola JA, et al. Assessment of Healthy and Harmful Maillard Reaction Products in a Novel Coffee Cascara Beverage: Melanoidins and Acrylamide. Foods (Basel, Switzerland). 2020;9(5):620. Available from: https://pubmed.ncbi.nlm.nih.gov/32408584
  11. Sasmito EH, Sawitri S. Clinical Manifestation and Management of Terrestrial Animal Bites. Berk Ilmu Kesehat Kulit dan Kelamin. 2021;33(2):135. Available from: http://dx.doi.org/10.20473/bikk.v33.2.2021.135-140
  12. Gelse K, Pöschl E, Aigner T. Collagens--structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003;55(12):1531-46. Available from: doi: 10.1016/j.addr.2003.08.002. PMID: 14623400.
  13. Shao Y, Qin Z, Alexander Wilks J, Balimunkwe RM, Fisher GJ, Voorhees JJ, et al. Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties. Exp Dermatol. 2018/07/29. 2019;28(8):914–21. Available from: https://pubmed.ncbi.nlm.nih.gov/29957839
  14. Philips N, Auler S, Hugo R, Gonzalez S. Beneficial regulation of matrix metalloproteinases for skin health. Enzyme Res. 2011;2011:427285. Available from: https://pubmed.ncbi.nlm.nih.gov/21423679
  15. Boo YC. Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies. Antioxidants (Basel, Switzerland). 2022;11(9):1663. Available from: https://pubmed.ncbi.nlm.nih.gov/36139737
  16. Farris PK. Topical Vitamin C: A Useful Agent for Treating Photoaging and Other Dermatologic Conditions. Dermatologic Surg. 2006;31:814–8. Available from: http://dx.doi.org/10.1111/j.1524-4725.2005.31725
  17. Lestari W, Hasballah K, Listiawan MY, Sofia S. Coffee by-products as the source of antioxidants: a systematic review. F1000Research. 2022;11:220. Available from: https://pubmed.ncbi.nlm.nih.gov/35646331
  18. Lestari W, Hasballah K, Listiawan MY, Sofia S. Identification of antioxidant components of Gayo Arabica Coffee Cascara using the GC-MS method. IOP Conf Ser Earth Environ Sci. 2022;956(1):12011. Available from: http://dx.doi.org/10.1088/1755-1315/956/1/012011
  19. Seleem M, Abulfadl YS, Hoffy N, Lotfy NM, Ewida HA. Promising role of topical caffeine mesoporous gel in collagen resynthesis and UV protection through proline assessment. Futur J Pharm Sci. 2022;8(1). Available from: http://dx.doi.org/10.1186/s43094-022-00417-5
  20. Chiang H-M, Lin T-J, Chiu C-Y, Chang C-W, Hsu K-C, Fan P-C, et al. Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway. Food Chem Toxicol. 2011;49(1):309–18. Available from: http://dx.doi.org/10.1016/j.fct.2010.10.034

How to Cite

Lestari, W., Hajar, S. ., Earlia, N. ., Asrizal, C. W. ., & Ritonga, M. A. . (2022). Effect of arabica Gayo coffee skin in repairing collagen damaged by UVB exposure. Bali Medical Journal, 12(1), 99–102. https://doi.org/10.15562/bmj.v12i1.3954
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
5

Total
3

Share

Search Panel

Wahyu Lestari
Google Scholar
Pubmed
BMJ Journal

Sitti Hajar
Google Scholar
Pubmed
BMJ Journal

Nanda Earlia
Google Scholar
Pubmed
BMJ Journal

Cynthia Wahyu Asrizal
Google Scholar
Pubmed
BMJ Journal

Muhammad Arif Ritonga
Google Scholar
Pubmed
BMJ Journal