Protective effect of lavender essential oils on depression and multi-organ stress

Hafid  Algristian; Tri Wahyuni  Bintarti; Rani Nur Mukaromatim  Baroroh; Qorieatul  Leila; Reina  Ulfa; Amelia Krismawati; Mifa  Nurdiana; Giftania Wardhani  Sudjarwo; Adhi Wibowo  Nurhidayat; Irawan Satriotomo; Retno  Handajani

doi:10.15562/bmj.v11i3.3655

Protective effect of lavender essential oils on depression and multi-organ stress

Hafid Algristian ,

Tri Wahyuni Bintarti ,

Rani Nur Mukaromatim Baroroh ,

Qorieatul Leila ,

Reina Ulfa ,

Amelia Krismawati ,

Mifa Nurdiana ,

Giftania Wardhani Sudjarwo ,

Adhi Wibowo Nurhidayat ,

Irawan Satriotomo ,

Retno Handajani ,

pdf |
DOI: https://doi.org/10.15562/bmj.v11i3.3655 |
Published: 2022-10-01

Abstract

Introduction: Lavender essential oils (LEO) have been known to have relaxing effects, improve mood, and treat anxiety, but the effect on multiple organ stress concurrently is unknown. This multiorgan stress is related to depression can be caused by chronic psychological stress due to excessive cortisol levels and can lead to organ damage. This study analyzed LEO in preventing depression and multiorgan failure using intraperitoneal injection of corticosteroids in animal-model.

Methods: Rats (Rattus norvegicus) Wistar strain, male, aged 7-8 weeks were involved in this study. Depression in animal-model is defined by immobilization using tail suspension test and anhedonia using sucrose preference test. LEO 5% was diluted in virgin coconut oils as vehicle. Serum cortisol was analyzed using enzyme-linked immunosorbent assay (ELISA). Organs were extracted and processed using hematoxylin eosin staining.

Results: The results of this study indicate that LEO was able to prevent damage to the glial cells, myocardiac cells, and gastrointestinal mast cells infiltration, but not to the hepatocytes and renal cells damage. LEO also induced behavioral activation as improvement of depression, but anhedonia was still remained.

Conclusion: The effect of LEO is to prevent the increase in blood cortisol levels, thus reduce the reactivity of depressed individuals to stress, although the individual still has anhedonia as a residual symptoms

References

Çorumlu U, Aydın OÖ, Ulupınar E. Effects of chronic unpredictable stress on intestinal morphology in Wistar rats. Anatomy. 2019;13(1):27–32.
Liang S, Wu X, Hu X, Wang T, Jin F. Recognizing depression from the microbiota–gut–brain axis. Int J Mol Sci. 2018;19(6).
Jaworski JL, Thompson LA, Weng H-Y. Quality of life of veterinary residents in AVMA-Recognized Veterinary Specialty Organizations using the WHOQOL-BREF instrument. PLoS One. 2022;17(5):e0268343. Available from: https://doi.org/10.1371/journal.pone.0268343
Alacreu-Crespo A, Olié E, Guillaume S, Girod C, Cazals A, Chaudieu I, et al. Dexamethasone Suppression Test May Predict More Severe/Violent Suicidal Behavior. Front Psychiatry. 2020;11:0–10.
Jafari-Koulaee A, Elyasi F, Taraghi Z, Ilali ES, Moosazadeh M. A Systematic Review of the Effects of Aromatherapy with Lavender Essential Oil on Depression. Cent Asian J Glob Heal. 2020;9(1).
Sánchez-Vidaña DI, Po KKT, Fung TKH, Chow JKW, Lau WKW, So PK, et al. Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. Neurosci Lett. 2019;701(February 2018):180–92.
Benedicto E. Use of essential oils as an alternative treatment for depression. Integr Med Alert. 2017;20(12):136–140.
Muscalu A, Tudora C, Petre A, Barcanu E, Mârzan O, Constantinescu E. Experimental Research Regarding the Harvest of Some Medicinal Plants From Fam. Lamiaceae. "Annals Univ Craiova - Agric Mont Ser ". 2020;51(2):67–72.
Bagheri-Nesami M, Shorofi SA, Nikkhah A, Espahbodi F. The effects of lavender essential oil aromatherapy on anxiety and depression in haemodialysis patients TT -. mazums-pbr. 2017;3(1):8–13. Available from: http://pbr.mazums.ac.ir/article-1-138-en.html
Nadirawati N. Pengaruh Aromaterapi Lavender Terhadap Depresi Pada Lansia Di Wilayah Kerja Puskesmas Citeureup Kota Cimahi 2015. Media Inf. 2016;12(1):1–7.
McCormick CM, Green MR, Simone JJ. Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence. Neurobiol Stress. 2017;6:31–43. Available from: http://dx.doi.org/10.1016/j.ynstr.2016.08.003
Charan J, Kantharia N. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4(4):303–6.
Zhao Y-N, Ma R, Shen J, Su H, Xing D, Du L. A mouse model of depression induced by repeated corticosterone injections. Eur J Pharmacol. 2008;581:113–20.
Chioca LR, Ferro MM, Baretta IP, Oliveira SM, Silva CR, Ferreira J, et al. Anxiolytic-like effect of lavender essential oil inhalation in mice: Participation of serotonergic but not GABAA/benzodiazepine neurotransmission. J Ethnopharmacol. 2013;147(2):412–8. Available from: https://www.sciencedirect.com/science/article/pii/S0378874113001840
Lesage-Meessen L, Bou M, Sigoillot J-C, Faulds CB, Lomascolo A. Essential oils and distilled straws of lavender and lavandin: a review of current use and potential application in white biotechnology. Appl Microbiol Biotechnol. 2015;99(8):3375–85.
Danh LT, Han LN, Triet NDA, Zhao J, Mammucari R, Foster N. Comparison of Chemical Composition, Antioxidant and Antimicrobial Activity of Lavender (Lavandula angustifolia L.) Essential Oils Extracted by Supercritical CO2, Hexane and Hydrodistillation. Food Bioprocess Technol. 2013;6(12):3481–9.
Silote G, Gatto M, Eskelund A, Guimarães F, Wegener G, Joca S. Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol. Pharmaceuticals. 2021;14:1269.
Antoniuk S, Bijata M, Ponimaskin E, Wlodarczyk J. Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neurosci Biobehav Rev. 2019;99:101–16.
Liu MY, Yin CY, Zhu LJ, Zhu XH, Xu C, Luo CX, et al. Sucrose preference test for measurement of stress-induced anhedonia in mice. Nat Protoc. 2018;13(7):1686–98.
Carneval L, Montano N, Statello R, Sgoifo A. Rodent models of depression-cardiovascular comorbidity: Bridging the known to the new. Neurosci Biobehav Rev. 2017;76:144–153.
Demirci T, Sahin E. Heart and stress: A morphometric and light microscopic study in a rat model. Averroes-EMJ. 2017;4.
Cantave CY, Langevin S, Marin M-F, Brendgen M, Lupien S, Ouellet-Morin I. Impact of maltreatment on depressive symptoms in young male adults: The mediating and moderating role of cortisol stress response and coping strategies. Psychoneuroendocrinology. 2019;103:41–8.
Ebrahimi H, Mardani A, Basirinezhad MH, Hamidzadeh A, Eskandari F. The effects of Lavender and Chamomile essential oil inhalation aromatherapy on depression, anxiety and stress in older community-dwelling people: A randomized controlled trial. Explore (NY). 2022;18(3):272–8.
Sayorwan W, Siripornpanich V, Piriyapunyaporn T, Hongratanaworakit T, Kotchabhakdi N, Ruangrungsi N. The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity. J Med Assoc Thai. 2012;95(4):598–606.
McMakin DL, Olino TM, Porta G, Dietz LJ, Emslie G, Clarke G, et al. Anhedonia Predicts Poorer Recovery Among Youth With Selective Serotonin Reuptake Inhibitor Treatment–Resistant Depression. J Am Acad Child Adolesc Psychiatry. 2012;51(4):404–11. Available from: https://www.sciencedirect.com/science/article/pii/S0890856712000469
Djuwita I, Riyacumala V, Mohamad K, Prasetyaningtijas W, Nurhidayat N. Growth and Protein Secretion from Primary Culture Rats Serebrum Cells. J Vet. 2012;13(2):125–35.
Kumalasari HP. Pengaruh pemberian sediaan pegagan (Centella asiatica (L) urban) terhadap histologis neuron otak tikus (Rattus norvegicus) yang mengalami nekrosis. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim. UIN Malang; 2012.
As N, Veterini L, Algristian H, Salim H. Brain-derived neurotrophic factor after long term stress exposure of Diabetes insipidus in patiens with traumatic severe brain injury Diabetes insipidus in patiens with traumatic severe brain injury Yudha Adi Prabowo1, Prananda Surya Airlangga2 depressed. Qanun Med. 2021;4(1):189–203.
Sierra H, Cordova M, Chen C-SJ, Rajadhyaksha M. Confocal imaging-guided laser ablation of basal cell carcinomas: an ex vivo study. J Invest Dermatol. 2015;135(2):612–5.
Sánchez-Vidaña DI, Ngai SP-C, He W, Chow JK-W, Lau BW-M, Tsang HW-H. The Effectiveness of Aromatherapy for Depressive Symptoms: A Systematic Review. Evid Based Complement Alternat Med. 2017;2017:5869315.
Indayani NS, Susilowati, Lestari SR. Pengaruh Pemberian Deksametason Terhadap Kerusakan Hepar Tikus Jantan (Rattus Norvegicus) Galur Wistar. Univ. Negeri Malang; 2015.
Rhind JP. Essential oils: A handbook for aromatherapy practice. Jessica Kingsley Publishers; 2012.
Ramsay DB, Stephen S, Borum M, Voltaggio L, Doman DB. Mast cells in gastrointestinal disease. Gastroenterol Hepatol. 2010;6(12):772–7.
Hartono JL, Mahadeva S, Goh K-L. Anxiety and depression in various functional gastrointestinal disorders: Do differences exist? J Dig Dis. 2012;13(5):252–7. Available from: https://doi.org/10.1111/j.1751-2980.2012.00581.x
Alhan C, Okan A. Irritable bowel syndrome, depression and anxiety. East J Med. 2017;22(3):125–9.
Karling P, Wikgren M, Adolfsson R, Norrback KF. Hypothalamus-pituitary-adrenal axis hypersuppression is associated with gastrointestinal symptoms in major depression. J Neurogastroenterol Motil. 2016;22(2):292–303.
Salvatore S, Barberi S, Borrelli O, Castellazzi A, Di Mauro D, Di Mauro G, et al. Pharmacological interventions on early functional gastrointestinal disorders. Ital J Pediatr. 2016;42(1):1–8. Available from: http://dx.doi.org/10.1186/s13052-016-0272-5
Ozdemir O. Sodium and Depression: Hypothetical Associations. Klin Psikofarmakol Bülteni-Bulletin Clin Psychopharmacol. 2013;23(1):107–12.
Abulmeaty MMA, Almajwal AM, Alnumair KS, Razak S, Hasan MM, Fawzy A, et al. Effect of long-term continuous light exposure and western diet on adropin expression, lipid metabolism, and energy homeostasis in rats. Biology (Basel). 2021;10(5).

[1] Çorumlu U, Aydın OÖ, Ulupınar E. Effects of chronic unpredictable stress on intestinal morphology in Wistar rats. Anatomy. 2019;13(1):27–32.

[2] Liang S, Wu X, Hu X, Wang T, Jin F. Recognizing depression from the microbiota–gut–brain axis. Int J Mol Sci. 2018;19(6).

[3] Jaworski JL, Thompson LA, Weng H-Y. Quality of life of veterinary residents in AVMA-Recognized Veterinary Specialty Organizations using the WHOQOL-BREF instrument. PLoS One. 2022;17(5):e0268343. Available from: https://doi.org/10.1371/journal.pone.0268343

[4] Alacreu-Crespo A, Olié E, Guillaume S, Girod C, Cazals A, Chaudieu I, et al. Dexamethasone Suppression Test May Predict More Severe/Violent Suicidal Behavior. Front Psychiatry. 2020;11:0–10.

[5] Jafari-Koulaee A, Elyasi F, Taraghi Z, Ilali ES, Moosazadeh M. A Systematic Review of the Effects of Aromatherapy with Lavender Essential Oil on Depression. Cent Asian J Glob Heal. 2020;9(1).

[6] Sánchez-Vidaña DI, Po KKT, Fung TKH, Chow JKW, Lau WKW, So PK, et al. Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. Neurosci Lett. 2019;701(February 2018):180–92.

[7] Benedicto E. Use of essential oils as an alternative treatment for depression. Integr Med Alert. 2017;20(12):136–140.

[8] Muscalu A, Tudora C, Petre A, Barcanu E, Mârzan O, Constantinescu E. Experimental Research Regarding the Harvest of Some Medicinal Plants From Fam. Lamiaceae. "Annals Univ Craiova - Agric Mont Ser ". 2020;51(2):67–72.

[9] Bagheri-Nesami M, Shorofi SA, Nikkhah A, Espahbodi F. The effects of lavender essential oil aromatherapy on anxiety and depression in haemodialysis patients TT -. mazums-pbr. 2017;3(1):8–13. Available from: http://pbr.mazums.ac.ir/article-1-138-en.html

[10] Nadirawati N. Pengaruh Aromaterapi Lavender Terhadap Depresi Pada Lansia Di Wilayah Kerja Puskesmas Citeureup Kota Cimahi 2015. Media Inf. 2016;12(1):1–7.

[11] McCormick CM, Green MR, Simone JJ. Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence. Neurobiol Stress. 2017;6:31–43. Available from: http://dx.doi.org/10.1016/j.ynstr.2016.08.003

[12] Charan J, Kantharia N. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4(4):303–6.

[13] Zhao Y-N, Ma R, Shen J, Su H, Xing D, Du L. A mouse model of depression induced by repeated corticosterone injections. Eur J Pharmacol. 2008;581:113–20.

[14] Chioca LR, Ferro MM, Baretta IP, Oliveira SM, Silva CR, Ferreira J, et al. Anxiolytic-like effect of lavender essential oil inhalation in mice: Participation of serotonergic but not GABAA/benzodiazepine neurotransmission. J Ethnopharmacol. 2013;147(2):412–8. Available from: https://www.sciencedirect.com/science/article/pii/S0378874113001840

[15] Lesage-Meessen L, Bou M, Sigoillot J-C, Faulds CB, Lomascolo A. Essential oils and distilled straws of lavender and lavandin: a review of current use and potential application in white biotechnology. Appl Microbiol Biotechnol. 2015;99(8):3375–85.

[16] Danh LT, Han LN, Triet NDA, Zhao J, Mammucari R, Foster N. Comparison of Chemical Composition, Antioxidant and Antimicrobial Activity of Lavender (Lavandula angustifolia L.) Essential Oils Extracted by Supercritical CO2, Hexane and Hydrodistillation. Food Bioprocess Technol. 2013;6(12):3481–9.

[17] Silote G, Gatto M, Eskelund A, Guimarães F, Wegener G, Joca S. Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol. Pharmaceuticals. 2021;14:1269.

[18] Antoniuk S, Bijata M, Ponimaskin E, Wlodarczyk J. Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neurosci Biobehav Rev. 2019;99:101–16.

[19] Liu MY, Yin CY, Zhu LJ, Zhu XH, Xu C, Luo CX, et al. Sucrose preference test for measurement of stress-induced anhedonia in mice. Nat Protoc. 2018;13(7):1686–98.

[20] Carneval L, Montano N, Statello R, Sgoifo A. Rodent models of depression-cardiovascular comorbidity: Bridging the known to the new. Neurosci Biobehav Rev. 2017;76:144–153.

[21] Demirci T, Sahin E. Heart and stress: A morphometric and light microscopic study in a rat model. Averroes-EMJ. 2017;4.

[22] Cantave CY, Langevin S, Marin M-F, Brendgen M, Lupien S, Ouellet-Morin I. Impact of maltreatment on depressive symptoms in young male adults: The mediating and moderating role of cortisol stress response and coping strategies. Psychoneuroendocrinology. 2019;103:41–8.

[23] Ebrahimi H, Mardani A, Basirinezhad MH, Hamidzadeh A, Eskandari F. The effects of Lavender and Chamomile essential oil inhalation aromatherapy on depression, anxiety and stress in older community-dwelling people: A randomized controlled trial. Explore (NY). 2022;18(3):272–8.

[24] Sayorwan W, Siripornpanich V, Piriyapunyaporn T, Hongratanaworakit T, Kotchabhakdi N, Ruangrungsi N. The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity. J Med Assoc Thai. 2012;95(4):598–606.

[25] McMakin DL, Olino TM, Porta G, Dietz LJ, Emslie G, Clarke G, et al. Anhedonia Predicts Poorer Recovery Among Youth With Selective Serotonin Reuptake Inhibitor Treatment–Resistant Depression. J Am Acad Child Adolesc Psychiatry. 2012;51(4):404–11. Available from: https://www.sciencedirect.com/science/article/pii/S0890856712000469

[26] Djuwita I, Riyacumala V, Mohamad K, Prasetyaningtijas W, Nurhidayat N. Growth and Protein Secretion from Primary Culture Rats Serebrum Cells. J Vet. 2012;13(2):125–35.

[27] Kumalasari HP. Pengaruh pemberian sediaan pegagan (Centella asiatica (L) urban) terhadap histologis neuron otak tikus (Rattus norvegicus) yang mengalami nekrosis. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim. UIN Malang; 2012.

[28] As N, Veterini L, Algristian H, Salim H. Brain-derived neurotrophic factor after long term stress exposure of Diabetes insipidus in patiens with traumatic severe brain injury Diabetes insipidus in patiens with traumatic severe brain injury Yudha Adi Prabowo1, Prananda Surya Airlangga2 depressed. Qanun Med. 2021;4(1):189–203.

[29] Sierra H, Cordova M, Chen C-SJ, Rajadhyaksha M. Confocal imaging-guided laser ablation of basal cell carcinomas: an ex vivo study. J Invest Dermatol. 2015;135(2):612–5.

[30] Sánchez-Vidaña DI, Ngai SP-C, He W, Chow JK-W, Lau BW-M, Tsang HW-H. The Effectiveness of Aromatherapy for Depressive Symptoms: A Systematic Review. Evid Based Complement Alternat Med. 2017;2017:5869315.

[31] Indayani NS, Susilowati, Lestari SR. Pengaruh Pemberian Deksametason Terhadap Kerusakan Hepar Tikus Jantan (Rattus Norvegicus) Galur Wistar. Univ. Negeri Malang; 2015.

[32] Rhind JP. Essential oils: A handbook for aromatherapy practice. Jessica Kingsley Publishers; 2012.

[33] Ramsay DB, Stephen S, Borum M, Voltaggio L, Doman DB. Mast cells in gastrointestinal disease. Gastroenterol Hepatol. 2010;6(12):772–7.

[34] Hartono JL, Mahadeva S, Goh K-L. Anxiety and depression in various functional gastrointestinal disorders: Do differences exist? J Dig Dis. 2012;13(5):252–7. Available from: https://doi.org/10.1111/j.1751-2980.2012.00581.x

[35] Alhan C, Okan A. Irritable bowel syndrome, depression and anxiety. East J Med. 2017;22(3):125–9.

[36] Karling P, Wikgren M, Adolfsson R, Norrback KF. Hypothalamus-pituitary-adrenal axis hypersuppression is associated with gastrointestinal symptoms in major depression. J Neurogastroenterol Motil. 2016;22(2):292–303.

[37] Salvatore S, Barberi S, Borrelli O, Castellazzi A, Di Mauro D, Di Mauro G, et al. Pharmacological interventions on early functional gastrointestinal disorders. Ital J Pediatr. 2016;42(1):1–8. Available from: http://dx.doi.org/10.1186/s13052-016-0272-5

[38] Ozdemir O. Sodium and Depression: Hypothetical Associations. Klin Psikofarmakol Bülteni-Bulletin Clin Psychopharmacol. 2013;23(1):107–12.

[39] Abulmeaty MMA, Almajwal AM, Alnumair KS, Razak S, Hasan MM, Fawzy A, et al. Effect of long-term continuous light exposure and western diet on adropin expression, lipid metabolism, and energy homeostasis in rats. Biology (Basel). 2021;10(5).

Protective effect of lavender essential oils on depression and multi-organ stress

Abstract

References

How to Cite

Search Panel