The effect of syzygium polyanthum (wight) extract in histological changes of kidney in diabetic mice model

David Sajid Muhammad; Hotimah Masdan Salim; Cici Dita Virlliana; Adyan Donastin; Agus Aan Adriansyah

doi:10.15562/bmj.v11i3.3545

The effect of syzygium polyanthum (wight) extract in histological changes of kidney in diabetic mice model

David Sajid Muhammad ,

Hotimah Masdan Salim ,

Cici Dita Virlliana ,

Adyan Donastin ,

Agus Aan Adriansyah ,

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DOI: https://doi.org/10.15562/bmj.v11i3.3545 |
Published: 2022-09-28

Abstract

Introduction: Diabetes mellitus, or hyperglycemia, is one of the risk factors for atherosclerosis, causing disruption of blood flow through arterial plaque formation and atherosclerosis. Diabetic kidney disease (DKD) is the most common cause of chronic and end-stage renal disease (CKD and ESRD) worldwide and is a stronger predictor of mortality in people with diabetes. Although the concept that the kidney plays a key role in glucose balance is not new, it is only recently that this organ has been viewed as a potential therapeutic target. This study aimed to assess the potential effect of Syzygium polyanthum extract in DKD mice model.

Methods: We administrated Syzygium polyanthum extract for 2-weeks to alloxan-induced diabetic mice.

Results: Treatment with Syzygium polyanthum extract reduced blood glucose levels in dose dependency (2,62mg/20g/day, 5,24mg/20g/day, and 7,86mg/20g/day). Histological analysis showed that Syzygium polyanthum extract significantly (p<0,05) improved the kidney lesions in low dose, but did not show a significant effect on inflammatory cell at glomerulus.

Conclusion: Syzygium polyanthum extract has potential to improve the kidney lesion in low dose and showed therapeutic potential in DKD treatment.

References

Nasri, H., Baradaran, A., Shirzad, H. & Rafieian-Kopaei, M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int. J. Prev. Med. 5, 1487–1499 (2014).
Wright, K., Norris, K. & Giger, J. N. A Comprehensive School Health Program to Reduce Disparities and Riskfor Type 2 Diabetes in Overweight At-Risk Youth. Endocrinol. Metab. Syndr. 2012, 1–6 (2012).
Yagi, S. et al. Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus. Adv. Ther. 35, 124–134 (2018).
Pourcel, L., Routaboul, J.-M., Cheynier, V., Lepiniec, L. & Debeaujon, I. Flavonoid oxidation in plants: from biochemical properties to physiological functions. Trends Plant Sci. 12, 29–36 (2007).
Salim, H. M., Kurnia, L. F., Bintarti, T. W., Handayani, H. & Shimabukuro, M. Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet. Trop. J. Nat. Prod. Res. 5, 2092–2095 (2022).
Ismail, A., Amir, W., Wan, N., Ismail, A. & Amir, W. Syzygium polyanthum ( Wight ) Walp : A Potential Phytomedicine COMMON NAMES AND PLANT. 11, 429–438 (2019).
Emelda, A. & Rika Astriani, Y. PHARMACEUTICAL JOURNAL OF INDONESIA Kombinasi Ekstrak Etanol Daun Salam (Syzygium polyanthum) dan Daun Jambu Biji (Psidium guajava L.) sebagai Antidiabetes Oral pada Tikus Putih (Rattus novergicus) Antihyperglicemic Activity of Combination of Syzygium pol. Pharm. J. Indones. 4, 17–22 (2018).
Lenzen, S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51, 216–226 (2008).
Waji, R., & S. Flavonoid (Quercetin), Laporan Kimia Organik Bahan Alam. (Universitas Hasanuddin, 2009).
Handani, A. R., Salim, M. N., Harris, A. & Budiman, H. PENGARUH PEMBERIAN KACANG PANJANG (Vigna unguiculata) TERHADAP STRUKTUR MIKROSKOPIS GINJAL MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN The Effect of Long Beans (Vigna unguiculata) on Kidney Microscopic Structure of Alloxan Induced Mice (Mus musculus). in (2015).
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[1] Nasri, H., Baradaran, A., Shirzad, H. & Rafieian-Kopaei, M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int. J. Prev. Med. 5, 1487–1499 (2014).

[2] Wright, K., Norris, K. & Giger, J. N. A Comprehensive School Health Program to Reduce Disparities and Riskfor Type 2 Diabetes in Overweight At-Risk Youth. Endocrinol. Metab. Syndr. 2012, 1–6 (2012).

[3] Yagi, S. et al. Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus. Adv. Ther. 35, 124–134 (2018).

[4] Pourcel, L., Routaboul, J.-M., Cheynier, V., Lepiniec, L. & Debeaujon, I. Flavonoid oxidation in plants: from biochemical properties to physiological functions. Trends Plant Sci. 12, 29–36 (2007).

[5] Salim, H. M., Kurnia, L. F., Bintarti, T. W., Handayani, H. & Shimabukuro, M. Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet. Trop. J. Nat. Prod. Res. 5, 2092–2095 (2022).

[6] Ismail, A., Amir, W., Wan, N., Ismail, A. & Amir, W. Syzygium polyanthum ( Wight ) Walp : A Potential Phytomedicine COMMON NAMES AND PLANT. 11, 429–438 (2019).

[7] Emelda, A. & Rika Astriani, Y. PHARMACEUTICAL JOURNAL OF INDONESIA Kombinasi Ekstrak Etanol Daun Salam (Syzygium polyanthum) dan Daun Jambu Biji (Psidium guajava L.) sebagai Antidiabetes Oral pada Tikus Putih (Rattus novergicus) Antihyperglicemic Activity of Combination of Syzygium pol. Pharm. J. Indones. 4, 17–22 (2018).

[8] Lenzen, S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51, 216–226 (2008).

[9] Waji, R., & S. Flavonoid (Quercetin), Laporan Kimia Organik Bahan Alam. (Universitas Hasanuddin, 2009).

[10] Handani, A. R., Salim, M. N., Harris, A. & Budiman, H. PENGARUH PEMBERIAN KACANG PANJANG (Vigna unguiculata) TERHADAP STRUKTUR MIKROSKOPIS GINJAL MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN The Effect of Long Beans (Vigna unguiculata) on Kidney Microscopic Structure of Alloxan Induced Mice (Mus musculus). in (2015).

[11] Waji, R. A. & Sugrani, A. Makalah Kimia Organik Bahan Alam Flavonoid (Quertecin). 23 (2019).

[12] Pham-Huy, L. A., He, H. & Pham-Huy, C. Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci. 4, 89–96 (2008).

[13] Chao, E. C. SGLT-2 Inhibitors: A New Mechanism for Glycemic Control. Clin. Diabetes 32, 4–11 (2014).

The effect of syzygium polyanthum (wight) extract in histological changes of kidney in diabetic mice model

Abstract

References

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