Background: Pregnant women infected with SARS-CoV-2 experienced increased pro-inflammatory cytokines, including TNF-α, resulting in a cytokine storm condition. This study aimed to compare TNF-α levels between pregnant women infected and not infected with COVID-19 in the third trimester.
Method: This observational research was conducted with cross sectional design. Our study included pregnant women who came to the delivery room/inpatient at Dr. Soetomo General Hospital Surabaya before or during labor between May and June 2021. The inclusion criteria were third trimester gestational age or >28 weeks with SARS-RT-PCR nasopharyngeal swab result. The exclusion criteria were all significant pregnancy complications. The pregnant woman coming to the delivery room will be screened for COVID-19, and blood samples will be examined using the flow cytometry method for the cytokine Th1: TNF-α.
Result: There were no significant differences in TNF-α levels in pregnant women who were infected and not infected with COVID-19 (median 3.42 (7.24) pg/ml vs. 2.70 (3.06) pg/ml. p=0.138). There was also no significant difference in TNF-α levels in pregnant women with symptomatic vs. asymptomatic COVID-19 infection (3.21(3.97) vs. 2.41(2.71) pg/ml; p=0.314).
Conclusion: This study revealed no significant difference in TNF-α serum level between SARS-CoV-2 infected pregnant women with normal pregnant women.