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The effect of Quran recitation on t-cell lymphocyte activity in mice model of breast cancer

Abstract

Introduction: Breast cancer is the leading cause of death in women. Many studies of adjuvant therapy have used the Quran recitation (later will be mentioned as the murotal approach). The murotal approach has been shown to induce feelings of well-being, enhance therapeutic response, and aid in patient healing. This study aimed to analyze the effect of the murotal approach on lymphocytic cell activity in inducing programmed cancer cell necrosis in a breast cancer mouse model.

Methods: After testing in a fully randomized design using 24 female mice (Mus musculus) BALB/c strain, a real-world experimental study with a control group design method. The mice were divided into four groups: negative control (K-), positive control (K+), treatment group (P1) which receiving the murotal approach for 2 hours and 30 minutes per day for a week, and the (P2) which receiving the murotal approach for 30 minutes in five times a day for a week. Mice were subcutaneously injected with DMBA 0.56 mg/20 g every 2 days for 3 weeks. The murotal approach was using specifically in Surah al-Faatihah and Al-Baaqarah from Qori' Al-Mathrud. Cancer tissue was harvested 5 weeks after her. The data were analyzed using the Kruskal-Wallis hypothesis test.

Results: There was a significant difference (P<0.05) in the effect between the P2 treatment group that received murotal therapy for 30 minutes at each prayer time and the other groups. The efficacy of treatment murotal for 2 hours and 30 minutes per day does not affect the extent of lymphocytic infiltration.

Conclusion: From the research, the dosage of murotal therapy to increase the degree of lymphocyte infiltration is for 30 minutes five times a day, or during prayer time.

References

  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249.
  2. Kementerian Kesehatan RI. Riset kesehatan dasar (RISKESDAS). Jakarta. 2018.
  3. The Global Cancer Observatory. Cancer Incident in Indonesia. 2020.
  4. Klaunig JE. Carcinogenesis, An Introd. to Interdiscip. Toxicol. pp. 97–110. 2020.
  5. Basu AK. DNA Damage, Mutagenesis and Cancer. Int J Mol Sci. 2018 Mar 23;19(4):970.
  6. Dent R, Valentini A, Hanna W, Rawlinson E, Rakovitch E, Sun P, Narod SA. Factors associated with breast cancer mortality after local recurrence. Curr. Oncol.2014; 21(3):p. e418.
  7. Pearce A, Haas M, Viney R, Pearson S, Haywood P, Brown C, Ward R. Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study. PLoS One. 2017; 12(10):p. e0184360.
  8. Algristian H, Wibowo R, Ishardyanto H, and Maramis MM. Do the Effectiveness of Psychotherapy to Women Patients with Locally Advanced Breast Cancer (LABC) is affected by Personality Traits and Meaning of Illness? in Konferensi Nasional II Psikiatri Religi dan Spiritual. 2017.
  9. Thornton LM, and Andersen BL. Psychoneuroimmunology examined: The role of subjective stress. Cellscience. 2006; 2(4): p. 66.
  10. Kruk J, Aboul-Enein BH, Bernstein J, and Gronostaj M. Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis. Oxid. Med. Cell. Longev. 2019; vol. 2019.
  11. Dhabhar FS. Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology. Allergy, Asthma Clin. Immunol. 2008; 4(1):pp. 1–10.
  12. Silberman DM, Wald MR, and Genaro AM. Acute and chronic stress exert opposing effects on antibody responses associated with changes in stress hormone regulation of T-lymphocyte reactivity. J. Neuroimmunol. 2003; 144(1): pp. 53–60.
  13. Tian W, Liu Y, Cao C, Zeng Y, Pan Y, Liu X, Peng Y, Wu F. Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments. Front Cell Dev Biol. 2021 Nov 19;9:777018.
  14. Zhang L, Pan J, Chen W, Jiang J, Huang J. Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment. Am J Cancer Res. 2020 May 1;10(5):1294-1307.
  15. Fares J, Fares MY, and Fares Y. Immune checkpoint inhibitors: Advances and impact in neuro-oncology. Surg. Neurol. Int. 2019; 10(1).
  16. Dewa Ayu Gede Putri Saraswati. Pengaruh terapi musik relaksasi instrumental terhadap tingkat kecemasan pasien stroke di ruang HCU BRSU Tabanan. Univ. Udayana. 2013.
  17. Rosani Senawati. Pengaruh Produk Daun Cincau Hijau Cyclea Barbata L. Miers Dan Premna Oblongifolio Merr Terhadap Kapasitas Antioksidan Sel Limfosit Mencit C3H Bertumor Kelenjar Susu. Inst. Pertan. Bogor. 2003.
  18. National Academic of Science (NAS). Laboratory Animal Management Rodents. Committee on Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences National Research Council. Washington DC: National Academy Press.
  19. Salgado R, Denkert C, Demaria S, Sirtaine N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL, Penault-Llorca F, Perez EA, Thompson EA, Symmans WF, Richardson AL, Brock J, Criscitiello C, Bailey H, Ignatiadis M, Floris G, Sparano J, Kos Z, Nielsen T, Rimm DL, Allison KH, Reis-Filho JS, Loibl S, Sotiriou C, Viale G, Badve S, Adams S, Willard-Gallo K, Loi S; International TILs Working Group 2014. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol. 2015 Feb;26(2):259-71.
  20. Dendreon. Cancer Immunotherapy: fundamental concepts and emerging role. Oncol. Perspect. 2013.
  21. Sholeh M. Terapi shalat tahajud. Jakarta: mizan publika. 2008.
  22. Azizah NAS, Veterini L, Algristian H, and Salim HM. Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review. Qanun Med. - Med. J. Fac. Med. Muhammadiyah Surabaya. 20221; 5(2): pp. 189–203.
  23. Mustajib A. Rahasia Dahsyat Terapi Otak. Jakarta: PT. Wahyu Media, 2010.

How to Cite

Muhammad, A. R. ., Palupi, Y. D. ., Astri, M. ., & Algristian, H. . (2022). The effect of Quran recitation on t-cell lymphocyte activity in mice model of breast cancer. Bali Medical Journal, 11(3), 1111–1115. https://doi.org/10.15562/bmj.v11i3.3473

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