Stem cell therapy is an emerging therapy in the medical field. Recent studies show that stem cell therapy gives promising results. One of the stem cell sources is the human umbilical cord that has many potential, not only for therapy alone but also for banking. Human umbilical cord mesenchymal stem cells (HUCMSCs) have greater advantages than bone marrow and adipose tissue-derived stem cells in isolating the cells and the shortest culture period. Studies on animal models showed improvement of kidney disease in the various mechanism. Human studies regarding human umbilical cord mesenchymal stem cells as therapy for kidney disease have not been conducted on a large scale, but MSC therapy appears safe.