Controlling blood pressure carried out by hypertensive patients is still less than 50%. It is related to the consumption of antihypertensive drugs. Adherence to medication is a critical factor in achieving blood pressure for resistant hypertension, but lifestyle modifications may be necessary to treat milder forms of hypertension. There are several factors that affect the anti-hypertensive medication adherence needs to be known. This study aims to analyze the findings regarding the factors that influence medication adherence in Hypertension sufferers. A literature review is done by looking for literature related to the theme taken. The databases used in the preparation of literature reviews are obtained from databases such as ProQuest, PubMed, EBSCO, and Google scholar. Search focuses on titles, keywords and articles that are appropriate in journals that have been determined from 2011-2021. Keywords used in the search for factor articles, adherence to taking medication and hypertension. The search results found 6 articles that had been selected based on predetermined inclusion and exclusion criteria. According to the review results, drug compliance plays an essential role in the long-term treatment of hypertension and can reduce the risk of complications. The finding of 11 factors influences medication adherence to Hypertension sufferers, including the level of knowledge, the role of health workers, motivation, family-friends support, attendance at the clinic, age, employment status, education level, belief, gender, and duration of suffering from Hypertension. Adherence to taking medication was measured by taking antihypertensive drugs in individuals, dietary behaviour, exercise, participation in posbindu/prolanis, and visits to health services for routine control. Compliance with drug use plays a vital role in the long-term treatment of hypertension to reduce the risk of complications The findings of 11 factors that influence medication adherence in patients with hypertension can be used as benchmarks for nurses to improve health services further to achieve optimal recovery.