ORIGINAL ARTICLE

Antioxidants and immunomodulatory effect of black cumin seed oil in at-risk metabolic syndrome

Akrom Akrom , Endang Darmawan, Nuril Maulida, Syuhada Syuhada

Akrom Akrom
Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia ; Ahmad Dahlan Drug Information and Research Center, Universitas Ahmad Dahlan, Yogyakarta, Indonesia. Email: akrom@pharm.uad.ac.id

Endang Darmawan
Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia

Nuril Maulida
Graduate Student, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia

Syuhada Syuhada
Graduate Student, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Online First: December 28, 2021 | Cite this Article
Akrom, A., Darmawan, E., Maulida, N., Syuhada, S. 2021. Antioxidants and immunomodulatory effect of black cumin seed oil in at-risk metabolic syndrome. Bali Medical Journal 10(3): 1042-1047. DOI:10.15562/bmj.v10i3.2822


Introduction: Black Cumin Seed Oil (BCSO) is a traditional medicine widely used as an antioxidant and immunomodulator. Objective: The purpose of this study is to investigate the effect of dose variation of BCSO (1.5 ml/day versus 3 ml/day) on IL-10 activity and MDA levels in patients at risk of MS at Jetis 1 Public Health Center (J1PHC), Bantul Regency, Yogyakarta, Indonesia.

Methods: We conducted an analytical cross-sectional study. 66 patients at risk of metabolic syndrome (MS) were divided into two groups. In stage 1, group 1 received a 1.5 ml/day dose, and group 2 received 3 ml/day for 20 days. The clinical parameters of MS, IL-10 activity, and MDA levels were measured at the end of the study stages.

Results: The mean activity of IL-10 in the 1.5 ml/day dose group was 4.83 and in the 3 ml/day dose group was 5.49, which showed an increase of around 13.66% (p = 0.300). The mean MDA level in the 1.5 ml/day group was 3.92 ?mol/L, which increased to 4.31 ?mol/L in the 3 ml/day group or approximately 9.95% (p = 0.802). Statistically, IL-10 activity and MDA levels in the two-dose groups did not differ significantly.

Conclusion: The results of this study indicate that the administration of BCSO at doses of 1.5 ml/day and 3 ml/day for 20 days has the same effect on IL-10 activity and MDA levels in patients at risk of MS. 

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