REVIEW

Keloid after orthopedic surgery: prevention, current therapy modalities, and emerging therapies modalities

Andrew Sutheno

Andrew Sutheno
Santo Antonius Hospital, West Kalimantan, Indonesia. Email: andrew.sutheno@gmail.com
Online First: April 28, 2021 | Cite this Article
Sutheno, A. 2021. Keloid after orthopedic surgery: prevention, current therapy modalities, and emerging therapies modalities. Bali Medical Journal 10(1): 225-228. DOI:10.15562/bmj.v10i1.2264


Keloid is a benign fibroproliferative tissue growth that exceeds the initial wound margins. It is caused by the disruption in the wound healing phase with increased fibroblast activity and excess collagen deposition. Keloid usually develops after tissue trauma. Orthopedic surgery inevitably causes tissue trauma that will lead to the formation of keloids in a few patients. Keloids can cause cosmetic and functional problems, thus interfere with a person's quality of life. Keloid therapy modalities are mainly divided into three, which are prophylactic therapy modalities, current therapy modalities, and emerging therapy modalities that are being developed. This literature review aims to evaluate further prevention, current therapy modalities, and emerging therapies modalities in Keloid following orthopedic surgery.

References

Shaheen A. Comprehensive review of keloid formation. Clin Res Dermatol. 2018;4(5):1–18.

Mari W, Alsabri SG, Tabal N, Younes S, Sherif A, Simman R. Novel insights on understanding of keloid scar: article review. J Am Coll Clin Wound Spec. 2016;7(1–3):1–7.

Akaa PD, Ahachi NC, Vhriterhire AR, Agada E, Jenrola AA. Five year retrospective study on keloid management. J Adv Med Med Res. 2017;23(6):1–8.

Grabowski G, Pacana MJ, Chen E. Keloid and Hypertrophic Scar Formation, Prevention, and Management : Standard Review of Abnormal Scarring in Orthopaedic. J Am Acad Orthop Surg. 2020;28:408–14.

Salati SA. Keloids – an extensive review in the light of recent. J Pakistan Assoc Dermatol. 2019;29(2):225–49.

Gauglitz G, Korting H. Hypertrophic scarring and keloids : pathomechanism and emerging treatment strategies. Mol Med. 2011;17(1–2):113–25.

Gürbüz H, Birtane M, Yalçın Ö. Evaluation of the Late Neurologic Deficits Accompanied by Hypertrophic Scars and Keloids in Children With Elbow Fractures. J Pediatr Orthop. 2001;(15):577–9.

Motoki THC, Isoldi FC, Filho AG, Ferreira LM. Keloid negatively affects body image. Burns. 2018;1–5.

Flick TR, Wang CX, Patel AH, Hodo TW, Sherman WF, Sanchez FL. Arthrofibrosis after total knee arthroplasty : patients with keloids at risk. J Orthop Traumatol. 2021;22(1):1–8.

Lee HJ, Jang YJ. Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci. 2018;19(3):1–19.

Huang C, Liu L, You Z, Du Y, Ogawa R. Managing keloid scars : from radiation therapy to actual and potential drug deliveries. Int Wound J. 2019;1–8.

Tripathi S, Soni K, Agrawal P, Gour V, Mondal R, Soni V. Hypertrophic scars and keloids : a review and current treatment modalities. Biomed Dermatology. 2020;4:1–11.

Lemperle G, Knapp D, Tenenhaus M. Minimal Scar Formation After Orthopaedic Skin Incisions Along Main Folding Lines. J Bone Jt Surg. 2019;101:392–9.

Rennekampff HO, Tenenhaus M. Theoretical basis for optimal surgical incision planning to reduce hypertrophic scar formation. Med Hypotheses [Internet]. 2020;140:1–4.

Hietanen KE, Järvinen TA, Huhtala H, Tolonen TT, Kuokkanen HO, Kaartinen IS. Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial. J Plast Reconstr Aesthetic Surg. 2019;72(1):4–11.

Khalid FA, Mehrose MY, Saleem M, Yousaf MA, Mujahid AM, Rehman SU, et al. Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. Burns. 2018;1–7.

Shah V V, Aldahan AS, Mlacker S, Alsaidan M. 5-fluorouracil in the treatment of keloids and hypertrophic scars : a comprehensive review of the literature. Dermatol Ther (Heidelb). 2016;6:169–83.

Bijlard E, Steltenpool S, Niessen F. Intralesional 5-fluorouracil in keloid treatment : a systematic review. Acta Derm Venereol. 2015;95:778–82.

Xu J, Yang E, Yu NZ, Long X. Radiation therapy in keloids treatment: history, strategy, effectiveness, and complication. Chin Med J. 2017;130(14):1715–21.

Forbat E, Ali F, Al-Niami F. Treatment of keloid scars using light-, laser- and energy-based devices : a contemporary review of the literature. Lasers Med Sci. 2017;32:2145–54.

Arno AI, Gauglitz GG, Barret JP, Jeschke MG. Up-to-date approach to manage keloids and hypertrophic scars : a useful guide. Burns [Internet]. 2014;1–12. Available from: http://dx.doi.org/10.1016/j.burns.2014.02.011

Gauglitz G, Bureik D, Dombrowski Y, Pavicic T, Ruzicka T, Schauber J. Botulinum toxin A for the treatment of keloids. Ski Pharmacol Physiol. 2012;25:313–8.

Chen J, Zhao S, Liu Y, Cen Y, Nicolas C. Effect of captopril on collagen metabolisms in keloid fibroblast cells. ANZ J Surg. 2016;86(12):1046–51.


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