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Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women

  • Dwi Ngestiningsih ,
  • Jessa Kris Dayanti ,
  • Lusiana Batubara ,


Abstract

Background: The aging process is associated with an increase in proinflammatory markers' serum levels, indicating that a chronic inflammatory process is correlated with an increase in disability, mortality, and frailty. Pro-inflammatory cytokines that increase with the incidence of frailty syndrome are IL-6, IL-1β and TNF-α. 25-hydroxyvitamin D (25 (OH) D) deficiency is also a potential risk factor for frailty, especially in the elderly. Vitamin D deficiency is associated with a risk of falling, which can speed up the frailty process. The aim of the study is to determine the relationship between IL-6, IL-1β and Vitamin D on frailty status in elderly women in elderly integrated health services (posyandu lansia), Semarang City.

Methods: This study used a cross sectional design with a consecutive sampling method of 27 subjects. Subjects measured vital signs, weight and height measurements. The study subjects were then taken venous blood to measure the levels of IL-6, IL-1β and vitamin D in blood serum and assessed their frailty status. Data analysis using SPSS 25 with Spearman correlation test.

Results: There were 27 elderly women who followed this study with an average age of 67.93 years. There are 16 people with pre-frail status and 3 people with frail status. There is a significant relationship between vitamin D levels in serum and frailty status (p = 0.008; r = 0.497). Variables IL-6 (p=0.328) and IL-1β (p=0.095) had no significant relationship with frailty status.

Conclusion: Most of the elderly women have a pre-frailty status, namely as much as 59.3%. Vitamin D levels in the body have a significant and unidirectional relationship with frailty status in elderly women.

Keywords: Vitamin D proinflammatory cytokines elderly frailty.

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How to Cite

Ngestiningsih, D., Dayanti, J. K., & Batubara, L. (2021). Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women. Bali Medical Journal, 10(1), 336–339. https://doi.org/10.15562/bmj.v10i1.2177
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Dwi Ngestiningsih
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Jessa Kris Dayanti
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Lusiana Batubara
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