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Relationship of gallbladder histopathology towards types of stones in cholelithiasis patients at Universitas Sumatera Utara Hospital, Medan, Indonesia

  • Adi Muradi Muhar ,
  • Denny Rifsal Siregar ,
  • Doddy Prabisma ,


Background: Cholelithiasis is a common disease of the gall bladder. It is estimated that around 10-15% of the population in western countries suffer from cholelithiasis. Types of gall bladder stones can be classified into cholesterol stones (containing cholesterol> 50%), mixed stones (containing 20-50% cholesterol), and pigment stones (containing cholesterol <20%). Cholelithiasis causes various histopathological changes in the gallbladder mucosa such as acute and chronic inflammation, Cholelithiasis, hyperplasia and carcinoma. The general objective of this study was to determine the histopathological relationship of the gallbladder to the type of stone in cholelithiasis patients at USU Hospital.

Method: The design in this study was cross-sectional. The sample of this study was 49 samples of patients with cholelithiasis who underwent cholecystectomy either by open cholecystectomy or per-laparoscopic cholecystectomy at Universitas Sumatera Utara (USU) Hospital. Gallstones and gall bladder will be examined in the laboratory. Data analysis will use the chi-square test.


Result: From 49 research samples found the most types of stones were mixed stones with 24 (49%) and histopathological results showed 18 examples (36.7%) were chronic inflammation. Based on the Chi-Square test found a significant relationship between the types of stones with histopathology of the gallbladder with a p-value of 0.001.


Conclusion: There is a significant relationship between the type of stone with histopathology in patients with cholelithiasis.



  1. William NS, O’Connel PR, Mc Caskie AW. The Gallbladdre and Bile Duct. In: Bailey & Love’s Short Practice of Suregry 27th Edition. CRC Press; 2018. p. 1188- 1199.
  2. Stinton LM, Shaffer EA. Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer. Gut Liver. 2012;6(2):172-187.
  3. Abbass S, Ahmad I, Gyedu A, Adae-Aboagye K, Badu-Peprah A. Prevalence of Cholelithiasis among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Africa Health Science. 2015;15:246-252.
  4. Kim SB, Kim KH, Kim TN, Heo J, Min KJ, Jung K. Sex Differences in Prevalence and Risk Factors of Asymptomatic Cholelithiasis in Korea Health Screening Examine: A Retrospective Analysis of A Multicenter Study. Medicine (Baltimore). 2017;96(13):e6477.
  5. Chandran PNK, Kuchhal M. An Extended Chemical Analysis Of Gallstone. Indian Journal of Clinical Biochemistry. 2007;22(2):145-150.
  6. Beena D, Shetty J, Bose V. Histopathological Spectrum of Diseases in Gallbladder. National Journal of Laboratory Medicine. 2017;6(4):6-9.
  7. Zaki M, Al Refeidi A. Histological changes in the human gallbladder epithelium associated with gallstones. OMJ. 2009;24(4):269-73.
  8. Baidya R, Sigdel B, Baidya NL. Histopathological Changes in Gallbladder Mucosa Associated with Cholelithiasis. Journal of Pathology of Nepal. 2012;2:224-225.
  9. Kereh DS, Lampus H, Sapan H, Loho LL. Correlation between stone type and mucosal histology change of gall bladder in gall stone patient. Biomedical Journal. 2015;7:41-47.
  10. Bravo E, Contardo J, Cea J. Frequency of cholelithiasis and biliary pathology in the easter island rapanui and non-rapanui population. Asian Pac J Cancer Prev. 2016;17(3):14588.
  11. Njeze GE. Gallstone. Nigerian Journal of Surgery. 2013;19(2):49-55.
  12. Völzke H, Baumeister SE, Alte D, et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005;71:97–105.
  13. Cirillo DJ, Wallace RB, Rodabough RJ, et al. Effect of estrogen therapy on gallbladder disease. JAMA. 2005;293:330–339.
  14. Karlatti SS, et al. Incidence of Various Types of Gallstones in Patients of Cholelithiasis in Belagavi. International Journal of Scientific Study. 2016;4:7: 21- 23.
  15. Atamanalp SS, Keles MS, Atamanalp RS, Acemoglu H, Laloglu E. The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration. Pak J Med Sci. 2013;29(1):187–190.
  16. Unisa S, Jagannath P, Dhir V, Khandelwal C, Sarangi L, Roy TK. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford). 2011;13(2):117-25.
  17. Barcia JJ. Histologic analysis of chronic inflammatory patterns in the gallbladder:diagnostic criteria for reporting cholecystitis. Ann Diagn Pathol 2003;7:147-53.
  18. Sunder G, Sanjeevsingle AD. Correlation between gallstones charecterestics and gallbladder mucosal changes : A retrospective study of 313 cases. Clin Cancer Investig J. 2014;3:157-161.

How to Cite

Muhar, A. M., Siregar, D. R., & Prabisma, D. (2021). Relationship of gallbladder histopathology towards types of stones in cholelithiasis patients at Universitas Sumatera Utara Hospital, Medan, Indonesia. Bali Medical Journal, 10(1), 1–3.




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Adi Muradi Muhar
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Denny Rifsal Siregar
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Doddy Prabisma
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