ORIGINAL ARTICLE

Vitamin D Receptor (VDR) Apa1 gene polymorphism increasing the risk of breast cancer women in Bali, Indonesia

I Putu Gede Fajar Mahayasa, I Ketut Widiana, Putu Anda Tusta Adiputra, I Wayan Sudarsa

I Putu Gede Fajar Mahayasa
Specialist Education Program of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Indonesia

I Ketut Widiana
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Indonesia

Putu Anda Tusta Adiputra
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Indonesia

I Wayan Sudarsa
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Indonesia. Email: sudarsa@unud.ac.id
Online First: February 19, 2021 | Cite this Article
Mahayasa, I., Widiana, I., Adiputra, P., Sudarsa, I. 2021. Vitamin D Receptor (VDR) Apa1 gene polymorphism increasing the risk of breast cancer women in Bali, Indonesia. Bali Medical Journal 10(1): 30-34. DOI:10.15562/bmj.v10i1.2113


Background: Breast cancer is the most common cancer diagnosed in women. It basically caused by a progressive accumulation of genetic disorders. Vitamin D and its receptor (VDR) have been shown to have an effect on the carcinogenesis of breast cancer. Several studies have shown VDR Apa1 polymorphisms became the most prevalent polymorphism of other polymorphism variants of breast cancer. There are still lack of studies that review the relationship of VDR gene polymorphisms, especially Apa1 on breast cancer risk among Balinese woman.

Method: This study was a case-control design- analytic study to see the relationship between Vitamin D receptor Apa1 gene polymorphism and breast cancer risk in Balinese women. There were 42 venous blood samples from breast cancer women and healthy women in Bali. This study was carried out at the Faculty of Medicine Integrated Biomedical Laboratory. DNA isolation was done for sequencing to determine the sequence of gene bases. Then the data were analyzed using SPSS 16.

Results: Univariate analysis showed the characteristics of the subject and research variables. Bivariate analysis showed that the presence of VDR Apa1 polymorphism in Balinese women increased the risk of breast cancer by 5,846-fold higher compared to women without polymorphism (CI95%:1.065- 32.082; P = 0.03). Multivariate analysis confirmed that the VDR Apa1 polymorphism independently influence and increase the risk of breast cancer without being influenced by other variables (95% CI: 1.065-32.082; P = 0.042).

Conclusion: In this study has shown VDR Apa1 polymorphism significantly associated and increased the risk of breast cancer in women in Bali.

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