REVIEW

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis

Mohammad Amin Bahrami , Abdollah Ansari, Kefayat Chaman-Ara, Elham Bahrami, Sima Bahrami, Mohammad Nabi Bahrami, Omid Barati, Mahmood Moosazadeh, Rauf O˘ guzhan Kum

Mohammad Amin Bahrami
Associate Professor, Healthcare Management Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email: mmoosazadeh1351@gmail.com

Abdollah Ansari
Resident of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Department of Otolaryngology, Head and neck surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Kefayat Chaman-Ara
Obstetrician and Gynecologist, Mehr Hospital, Borazjan, Iran

Elham Bahrami
Obstetrician and Gynecologist, Ayatollah Khatami Hospital, Yazd, Iran

Sima Bahrami
Medicine Student, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mohammad Nabi Bahrami
Orthopaedic Resident, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Omid Barati
Assistant Professor, Healthcare Management Department, Shiraz University of Medical Sciences, Shiraz, Iran

Mahmood Moosazadeh
Assistant Professor, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

Rauf O˘ guzhan Kum
Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey
Online First: April 30, 2016 | Cite this Article
Bahrami, M., Ansari, A., Chaman-Ara, K., Bahrami, E., Bahrami, S., Bahrami, M., Barati, O., Moosazadeh, M., guzhan Kum, R. 2016. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. Bali Medical Journal 5(2): 197-201. DOI:10.15562/bmj.v5i2.198


Background: Sudden sensorineural hearing loss (SSNHL) is a common otologic disease characterized by a loss of hearing greater than 30 dB in three consecutive frequen­cies which occurs in less than 72 hours. Objective: To investigate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on sudden sensorineural hearing loss (SSNHL). Search strategy: A PubMed, Science Direct, Scopus, OVID, EMBASE and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All case-control studies, which have been investigated the relationship of NLR and PLR with the occurrence of SSNHL were included in our meta-analysis. Results: A total of 5 case-control studies were included in the study. All 5 studies have been reported NLR of patients and control groups (611 patients and 804 controls). Our analysis showed that the mean NLR of patients is 1.12 (0.82-1.43) unit higher than that of controls with 95% CI which is statistically significant. Also, 3 studies have been reported PLR of patients and control groups (512 patients and 705 controls). Our analysis showed that the mean PLR of patients is 0.57 (0.08-1.05) unit higher than that of controls with 95% CI which is statistically significant too. Conclusions: This meta-analysis confirmed the relationship of NLR and PLR with SSNHL. Therefore, these parameters can be considered as new markers in diagnosis of SSNHL. 

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