Investigation of Astaxanthin effect on the formation of collagen fibers for periodontal tissue repair in bacteria infected periodontitis
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- DOI: https://doi.org/10.15562/bmj.v9i2.1770 |
- Published: 2020-08-01
Open Access & Peer Reviewed Multidisciplinary
Journal of Medical Sciences
Journal of Medical Sciences
Abstract
Introduction: Periodontitis is an inflammation of periodontal tissue in which the attachment-forming ligament composed of collagen fibers is damaged. Inflammation is a scenario where oxidative stress is abundant which may worsen periodontitis. Antioxidant, such as astaxanthin, is needed to promote collagen fibers formation as a sign of healing.
Objective: To explore whether astaxanthin has a desirable effect in the formation of collagen fibers in bacteria-triggered periodontitis in rats.
Methods: An animal experimental study were conducted. There were 3 groups, each consisted of 8 rats: negative control, positive control, and treated group. The treated group received oral preparation of astaxanthin 0,54 mg/kg/day for 7 days. The rats were then sacrificed, and the periodontal tissue were made into paraffin-fixed 5 µm tick slides with hematoxylin eosin staining and trichromone masson to evaluate the collagen expression. The evaluation was carried out by a pathologist.
Results: There is a significant difference of collagen expression level between the T and PC groups (p-value<0.05)
Conclusion: There is a significant difference between the groups treated with astaxanthin and the group with periodontitis disease.
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How to Cite
Susanti, W., Purwanto, B., Cilmiaty, R., & Prayitno, A. (2020). Investigation of Astaxanthin effect on the formation of collagen fibers for periodontal tissue repair in bacteria infected periodontitis. Bali Medical Journal, 9(2), 493–495. https://doi.org/10.15562/bmj.v9i2.1770
