Background: Polyalkylimide is a permanent dermal filler that has been used for skin augmentation to ameliorate skin ageing. The massive volume injection has a higher risk of complication. This study aims to find collagen capsule formation by small volume polyalkylimide implantation.Â Â
Methods: We used an experimental post-test only control group design. The control group received subcutaneous NaCl injection, and the treatment group received subcutaneous polyalkylimide injection 0.018 mL (equal 1 mL in the humans). After five weeks, all rats (Rattus norvegicus) strain Wistar were sacrificed. The skin samples were collected and proceed for histologic staining. Capsule thickness was performed as mean Â± SD.Â Â Â Â Â
Results: The treatment group showed polyalkylimide mass in subcutaneous tissue, collagen fibres surrounding the polyalkylimide, and no inflammatory cells. The collagen capsule thickness was 7.45 Â± 0.78 Âµm.
Conclusion: The small volume polyalkylimide subcutaneous injection-induced collagen capsule formation. The small volume implantation shows promising effects for skin augmentation.