Background: Ischemic stroke is a clinical syndrome with rapid brain function loss due to a disturbance of blood supply to the brain. The role of natural anticoagulants protein C, protein S and antithrombin III (AT III) in ischemic stroke is still unknown. This study aimed to determine the differences in the levels of protein C, protein S and AT III, which were examined on days 1, 3 and 7 of acute ischemic stroke during treatment.
Methods: This was a longitudinal prospective study carried out in Haj Adam Malik General Hospital Medan, from January to May 2018. This study included 21 acute ischemic stroke patients with three times of sampling (day 1, 3 and 7). Protein C, protein S and AT III were examined using the Coatron A4 device. Protein C and AT III were examined using chromogenic assay principles and protein S using clotting assay principles.
Results: Twenty-one patients who participated in this study were 12 men (57.1%) and nine women (42.9%). There was no significant difference in the level of protein C (p = 0.980), protein S (p = 0.680) and AT III (p = 0.872) between day 1, 3, and 7. There was a positive correlation in protein C, protein S and AT III levels between day 1, 3, and 7. There was a negative correlation between protein C and AT III levels on day 3 (r: - 0.498; p: 0.022).Conclusion: There was no significant difference in the level of protein C, protein S and antithrombin III between day 1, 3, and 7.