Analysis of serum 25-Hydroxyvitamin D level in keloid patients

Vira Indhiratamin Damanik; Imam B Putra; Oratna Ginting

doi:10.15562/bmj.v8i1.1360

Analysis of serum 25-Hydroxyvitamin D level in keloid patients

Vira Indhiratamin Damanik ,

Imam B Putra ,

Oratna Ginting ,

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DOI: https://doi.org/10.15562/bmj.v8i1.1360 |
Published: 2009-04-01

Abstract

Background: Keloid is solid fibrous tissue tumors that occur due to an imbalance between deposition and degradation of extracellular matrix components, especially collagen. Vitamin D is known to have a beneficial role in slowing the progression of tissue fibrosis and proven to play an important role in the synthesis and degradation of collagen and acts as an anti-inflammatory mediator.

Aim: To determine the difference between serum 25-hydroxyvitamin D level in keloid patients and controls.

Method: This is a cross-sectional analytic study involving 60 subjects consist of 30 keloid patients and 30 controls. Keloid patients were diagnosed by history and clinical examinations, and we conducted blood sampling and measurement of serum 25-hydroxyvitamin D level to the patients and controls.

Results: The mean of serum 25-hydroxyvitamin D level in keloid patients (16.92 Â± 5.96 ng/mL) was significantly lower than controls (23.57 Â± 6.72 ng/mL), p=0.0001

Conclusion: Serum 25-hydroxyvitamin D level in keloid patients was significantly lower than controls, serum 25-hydroxyvitamin D level in keloid patients was higher in the male group, aged 31-35 years group, duration of disease between 6-10 years group and positive family history.

References

Burrows NP, Lovell CR. Disorders of Connective Tissue. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rookâ€™s Textbook of Dermatology. 8th ed. Oxford: Wiley-Blackwell; 2010.p.45.1-70.
Seo BF, Lee JY, Jung SN. Models of Abnormal Scarring.
BioMed Research International. 2013; Article ID 423147: 1-8. doi.org/10.1155/2013/423147.
Seifert O, Mrowietz U. Keloid scarring: bench and bedside. Arch Dermatol Res. 2009; 301: 259-72. doi: 10.1007/s00403-009-0952-8
Halim AS, Emami A, Salahshourifar I, Kannan TP. Keloid Scarring: Understanding the Genetics Basic, Advances, and Prospects. Arch Plast Surg. 2012;39:184-9. http://dx.doi.org/10.5999/aps.2012.39.3.184.
Yu D, Shang Y, Luo S, Hao L. The TaqI Gene Polymorphisms of VDR and the Circulating 1,25-Dihidroxyvitamin D Levels Confer the Risk for Keloid Scarring in Chinese Cohorts. Cell Physiol Biochem. 2013;32:39-45. doi: 10.1159/00035012.
Koleganova N, Piecha G, Ritz E, Gross M. Calcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats. Nephrol Dial Transplant. 2009;24: 778-87. doi: 10.1093/ndt/gfn549.
Dong X, Mao S, Wen H. Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomedical Reports. 2013;1:833-6. DOI: 10.3892/br.2013.169
Cooke GL, Chien A, Brodsky A, Lee RC. Incidence of Hypertrophic Scars among African Americans Linked to Vitamin D-3 Metabolism? [Internet]. 2005 [cited 2017 Feb 5] ;97(7):1004-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569323.
Tsiaras WG, Weinstock MA. Factors Influencing Vitamin D Status. Acta Derm Venerol. 2011; 91: 115-24. doi: 10.2340/00015555-0980.
Medikawati IGAAR, Praharsini IGAA, Wardhana M. Kadar 25-hydroxyvitamin D Plasma Berkorelasi Negatif dengan Derajat Keparahan pada Penderita Keloid [thesis]. Denpasar:Universitas Udayana;2015.
Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int. 2009;20:133-40. doi: 10.1007/s00198-008-0626-y
Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J. The Dependency of Vitamin D Status on Body Mass Index, Gender, Age and Season. Anticabcer Research. 2009;29:3713-20.
Lee DE, Trowbridge RM, Ayoub NT, Agrawal DK. High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scar. PRS Global Open. 2015;1-9.

[1] Burrows NP, Lovell CR. Disorders of Connective Tissue. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rookâ€™s Textbook of Dermatology. 8th ed. Oxford: Wiley-Blackwell; 2010.p.45.1-70.

[2] Seo BF, Lee JY, Jung SN. Models of Abnormal Scarring.

[3] BioMed Research International. 2013; Article ID 423147: 1-8. doi.org/10.1155/2013/423147.

[4] Seifert O, Mrowietz U. Keloid scarring: bench and bedside. Arch Dermatol Res. 2009; 301: 259-72. doi: 10.1007/s00403-009-0952-8

[5] Halim AS, Emami A, Salahshourifar I, Kannan TP. Keloid Scarring: Understanding the Genetics Basic, Advances, and Prospects. Arch Plast Surg. 2012;39:184-9. http://dx.doi.org/10.5999/aps.2012.39.3.184.

[6] Yu D, Shang Y, Luo S, Hao L. The TaqI Gene Polymorphisms of VDR and the Circulating 1,25-Dihidroxyvitamin D Levels Confer the Risk for Keloid Scarring in Chinese Cohorts. Cell Physiol Biochem. 2013;32:39-45. doi: 10.1159/00035012.

[7] Koleganova N, Piecha G, Ritz E, Gross M. Calcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats. Nephrol Dial Transplant. 2009;24: 778-87. doi: 10.1093/ndt/gfn549.

[8] Dong X, Mao S, Wen H. Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomedical Reports. 2013;1:833-6. DOI: 10.3892/br.2013.169

[9] Cooke GL, Chien A, Brodsky A, Lee RC. Incidence of Hypertrophic Scars among African Americans Linked to Vitamin D-3 Metabolism? [Internet]. 2005 [cited 2017 Feb 5] ;97(7):1004-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569323.

[10] Tsiaras WG, Weinstock MA. Factors Influencing Vitamin D Status. Acta Derm Venerol. 2011; 91: 115-24. doi: 10.2340/00015555-0980.

[11] Medikawati IGAAR, Praharsini IGAA, Wardhana M. Kadar 25-hydroxyvitamin D Plasma Berkorelasi Negatif dengan Derajat Keparahan pada Penderita Keloid [thesis]. Denpasar:Universitas Udayana;2015.

[12] Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int. 2009;20:133-40. doi: 10.1007/s00198-008-0626-y

[13] Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J. The Dependency of Vitamin D Status on Body Mass Index, Gender, Age and Season. Anticabcer Research. 2009;29:3713-20.

[14] Lee DE, Trowbridge RM, Ayoub NT, Agrawal DK. High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scar. PRS Global Open. 2015;1-9.

Analysis of serum 25-Hydroxyvitamin D level in keloid patients

Abstract

References

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