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Concentrations of endothelin-1 associated with aging of prehypertension patients in Denpasar and Badung Districts, Bali, Indonesia.

Abstract

Hypertension is a major health problem in the world. Prehypertension increases the risk of developing hypertension with a high blood pressure. Aging often occurs with an elevation of blood pressure. Endothelin-1 is a strong vascular vasoconstrictor which its concentration is related to various cardiovascular diseases including hypertension. However, it is still unclear whether aging is related to endothelin-1 activation. Therefore, the aim of this study is to determine the correlation between age and serum endothelin-1 concentration in patients with prehypertension.

This is a community-based and cross-sectional study which was conducted in Denpasar and Badung regencies, Bali-Indonesia. A total of 75 prehypertension patients were involved in the consecutive study.

Spearman Correlation analysis demonstrated that age was strongly correlated with endhotelin-1 levels in the patients with prehypertension, R = 0.290 (p = 0.012). Age was also positively correlated with systolic blood pressure R = 0.235 (p = 0.042). In contrast, there was no correlation between age with diastolic blood pressure, R = 0.037 (p = 0.750).

In conclusion, endothelin-1 concentration increased in patients with prehypertension. This condition also caused an elevation of blood pressure.   

How to Cite

Yenny, L. G. S. (2019). Concentrations of endothelin-1 associated with aging of prehypertension patients in Denpasar and Badung Districts, Bali, Indonesia. Bali Medical Journal, 8(1), 287–290. https://doi.org/10.15562/bmj.v8i1.1340

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Luh Gede Sri Yenny
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