ORIGINAL ARTICLE

Concentrations of endothelin-1 associated with aging of prehypertension patients in Denpasar and Badung Districts, Bali, Indonesia.

Luh Gede Sri Yenny

Luh Gede Sri Yenny
Department of Physiology and Biochemistry, Faculty of Medicine and Health Sciences, Warmadewa. Email: sriyenny82@yahoo.com
Online First: April 01, 2019 | Cite this Article
Yenny, L. 2019. Concentrations of endothelin-1 associated with aging of prehypertension patients in Denpasar and Badung Districts, Bali, Indonesia.. Bali Medical Journal 8(1): 287-290. DOI:10.15562/bmj.v8i1.1340


Hypertension is a major health problem in the world. Prehypertension increases the risk of developing hypertension with a high blood pressure. Aging often occurs with an elevation of blood pressure. Endothelin-1 is a strong vascular vasoconstrictor which its concentration is related to various cardiovascular diseases including hypertension. However, it is still unclear whether aging is related to endothelin-1 activation. Therefore, the aim of this study is to determine the correlation between age and serum endothelin-1 concentration in patients with prehypertension.

This is a community-based and cross-sectional study which was conducted in Denpasar and Badung regencies, Bali-Indonesia. A total of 75 prehypertension patients were involved in the consecutive study.

Spearman Correlation analysis demonstrated that age was strongly correlated with endhotelin-1 levels in the patients with prehypertension, R = 0.290 (p = 0.012). Age was also positively correlated with systolic blood pressure R = 0.235 (p = 0.042). In contrast, there was no correlation between age with diastolic blood pressure, R = 0.037 (p = 0.750).

In conclusion, endothelin-1 concentration increased in patients with prehypertension. This condition also caused an elevation of blood pressure.   

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