ORIGINAL ARTICLE

The effect of mustard greens (Brassica rapa l.) ethanol extract on blood glucose and malondialdehyde levels of hyperglycemic Wistar rats

Sri Wahjuni, I Wayan Gede Gunawan, Ika Yolanda Dewi Malindo

Sri Wahjuni
Chemistry Department, Program FMIPA Udayana University, Bukit Jimbaran, Bali

I Wayan Gede Gunawan
Chemistry Department, Program FMIPA Udayana University, Bukit Jimbaran, Bali

Ika Yolanda Dewi Malindo
Chemistry Department, Program FMIPA Udayana University, Bukit Jimbaran, Bali. Email: ikayolanda144@gmail.com
Online First: April 01, 2019 | Cite this Article
Wahjuni, S., Gunawan, I., Malindo, I. 2019. The effect of mustard greens (Brassica rapa l.) ethanol extract on blood glucose and malondialdehyde levels of hyperglycemic Wistar rats. Bali Medical Journal 8(1): 35-40. DOI:10.15562/bmj.v8i1.1320


Purpose: This study aims to determine the effect of mustard greens ethanol extract (Brassica rapa L.) in reducing blood glucose and malondialdehyde levels in hyperglycemic Wistar rats.

Methods: The hyperglycemic Wistar rats were divided into 5 groups. Normal groups, positive control group (given glibenclamide) and treatment group were given orally with mustard extract with a dose of dose of 10mg/KgBW, 15 mg/KgBW, and 20 mg/KgBW.

Results and Discussion: The ethanol extract of green mustard with a dose of 10, 15, and 20 mg/KgBW reduced 49.60 mg/dl; 74.00 mg/dl; 101.20 mg/dl blood glucose levels, respectively and 6.31 nmol/ml; 6.43 nmol/ml; 7.14 nmol/ml malondialdehyde levels. The phenol groups contained in the extract was hypothesized to be the key for blood glucose levels reduction by the mechanism of capturing or neutralizing the excess free radical in hyperglycemic Wistar rats.

Conclusion: One Way ANOVA analysis and Post Hoc Study showed that ethyl acetate fraction of mustard greens extract dose of 10, 15, and 20 mg/KgBW were able to significantly reduce blood glucose and malondialdehyde levels in hyperglycemic Wistar rats (p<0.05).

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