ORIGINAL ARTICLE

Correlation between serum S100β protein level with neurological deficit in patients with acute intracerebral hemorrhage

Poppy Kristina Sasmita , Ismail Setyopranoto, Samekto Wibowo, Ahmad Hamim Sadewa

Poppy Kristina Sasmita
Doctorate Program of Medical and Health Science, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. Department of Anatomy, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. Email: poppyksasmita@yahoo.com

Ismail Setyopranoto
Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Samekto Wibowo
Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Ahmad Hamim Sadewa
Department of Biochemistry, Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia
Online First: December 04, 2018 | Cite this Article
Sasmita, P., Setyopranoto, I., Wibowo, S., Sadewa, A. 2018. Correlation between serum S100β protein level with neurological deficit in patients with acute intracerebral hemorrhage. Bali Medical Journal 8(1): 63-68. DOI:10.15562/bmj.v8i1.1249


Purpose: This study aimed to assess the relationship between S100β protein with neurological
deficit and mortality within 1 week in patients with Intracerebral hemorrhage (ICH) stroke. And
also, to determine the relationship between hematoma volume with S100β protein.
Patients and Methods: a prospective observational cohort study. Patients with sampling from
consecutive admission from August 2016 to December 2017 were performed head CT Scan, met
inclusion and exclusion criteria. Neurological deficits as ascertained with National Institute of
Health Stroke Scale (NIHSS). Blood samples were taken at the admission to the hospital and on the
7th day of onset.
Results: There were 46 patients with 25 men (54.3%) and 42 controls with a median age of 56 (31-
76) and 34.5 (21-67) years. The most risk factor was hypertension (78,3%). Median onset of acute
ICH stroke was 8.5 (0.5-48) hours. Median level of consciousness according to Glasgow Coma
Scale (GCS) at the admission to the hospital was 14 (3-15) and the NIHSS was 11.50 (0-37). Serum
S100β protein levels correlated significantly with NIHSS (r=0.418;p=0.004). Area Under Curve
(AUC) of S100β was 0.839±0.103 (95% CI, 0.638-1.000), cutoff level was 28,505 pg/mL with 80%
sensitivity and 87.8% specificity (p=0.014). Serum S100β protein levels associated significantly
with mortality within 1 week (p=0.032). The hematoma volume correlated with S100β protein
levels (r=0.678;p<0.001).
Conclusion: S100β protein was significant correlation with neurological deficits. S100β protein
was associated significantly with mortality within 1 week. The hematoma volume was significant
correlation with S100β protein.

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