ORIGINAL ARTICLE

Effect of a combination of arterial hypertension and insulin resistance on hemostasis activity

Svetlana Yurevna Zavalishina , Yuri Anatolyevich Vatnikov, Evgeniy Vladimirovich Kulikov, Tursumbay Satimbaevich Kubatbekov, Ilya Fedorovich Vilkovysky, Alexander Konstantinovich Petrov, Andrey Leonidovich Tishchenko, Stanislav Gennadievich Drukovsky, Andrei Nikolaevich Zharov, Victor Nikolaevich Grishin, Tatyana Ivanovna Glagoleva

Svetlana Yurevna Zavalishina
Russian State Social University, Moscow, Russia. Email: svetlanazsyu@mail.ru

Yuri Anatolyevich Vatnikov
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Evgeniy Vladimirovich Kulikov
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Tursumbay Satimbaevich Kubatbekov
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Ilya Fedorovich Vilkovysky
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Alexander Konstantinovich Petrov
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Andrey Leonidovich Tishchenko
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Stanislav Gennadievich Drukovsky
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Andrei Nikolaevich Zharov
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Victor Nikolaevich Grishin
Peoples Friendship University of Russia (RUDN University), Moscow, Russia

Tatyana Ivanovna Glagoleva
All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals, Institute of village, Borovsk, Russia
Online First: December 20, 2018 | Cite this Article
Zavalishina, S., Vatnikov, Y., Kulikov, E., Kubatbekov, T., Vilkovysky, I., Petrov, A., Tishchenko, A., Drukovsky, S., Zharov, A., Grishin, V., Glagoleva, T. 2018. Effect of a combination of arterial hypertension and insulin resistance on hemostasis activity. Bali Medical Journal 8(1): 211-215. DOI:10.15562/bmj.v8i1.1151


Lasting existence of arterial hypertension in combination with insulin-resistance inevitably disturbs functioning of all the hemostasis elements. Weakening of vascular control over platelets’ aggregation, hemocoagulation and fibrinolysis is noted in these conditions. Production lowering of substances with thrombo-resistant properties in vessels, increase of endothelium permeability for macromolecules, accumulation of lipoproteins in vascular wall, adhesion of platelets and leucocytes to it lie in the basis of it. Patients with arterial hypertension and insulin-resistance are characterized by platelets’ activation leading to the increase of circulating platelets with changed surface structure in blood and their aggregates. In the given category of patients it is caused by the increased content of biologically active substances in platelets and number increase of different receptors on their surface, including fibrinogen. Combination of arterial hypertension with insulin-resistance inevitably disturbs functioning of coagulative component of hemostasis system – the content of fibrinogen, VII, VIII, IX factors of coagulation, von Willebrand’s Factor increases in blood at activity lowering of antithrombin III, protein C and protein S. The complexity of hemostasiopathy in arterial hypertension and insulin resistance dictate the need to continue the search for therapeutic approaches which can balance thrombophilia and simultaneously affect all the components of the hemostatic system.
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