RESEARCH LETTER

Influence of zinc supplementation in eosinophil nasal mucous count and quality of life in moderate to severe persistent allergic rhinitis patient in ENT clinic Dr. Kariadi hospital Semarang in November 2016 until January 2017

Atik Masdarinah Sudadi , Riece Hariyati, Anna Mailasari Kusuma Dewi

Atik Masdarinah Sudadi
ENT Departement, Faculty of Medicine Diponegoro University-Kariadi General Hospital.. Email: atik.masdarinah@yahoo.com

Riece Hariyati
ENT specialist, Faculty of Medicine Diponegoro University-Kariadi Hospital.

Anna Mailasari Kusuma Dewi
ENT specialist, Faculty of Medicine Diponegoro University-Kariadi Hospital.
Online First: April 01, 2019 | Cite this Article
Sudadi, A., Hariyati, R., Dewi, A. 2019. Influence of zinc supplementation in eosinophil nasal mucous count and quality of life in moderate to severe persistent allergic rhinitis patient in ENT clinic Dr. Kariadi hospital Semarang in November 2016 until January 2017. Bali Medical Journal 8(1): 88-93. DOI:10.15562/bmj.v8i1.1127


Background : Allergic rhinitis is an inflammation in nasal mucous caused by allergen exposure. Eosinophil has a role the allergic reaction. Examination of eosinophil nasal mucus is a cytologic  investigation to diagnose AR. Zink is a micro, and essential nutrient with anti- inflammatory effect suggest to reduce eosinophil nasal mucous and increase the quality of life.Objectives : To determine the effect of zinc supplementation on a mount of eosinophil nasal mucous and quality of life in moderate to severe persistent allergic rhinitis patient. Methods : A single-blinded intervention study pre-test and post-test design.The treatment of zinc 40 mg/24 hour  in the moderate to severe persistent allergic rhinitis patient with cetirizine (experimental group) is compare with treatment of cetirizine only (control group). The examination of the zinc serum count of nasal  mucous eosinophil and the quality of life  in the first and second week after the treatment was compare beetwen the two groups. Result :A total of 34 subjects included in the study. There was a significant decrease in the eosinophil count of nasal mucus in experimental group (p=0.002) and the control group (p=0.001). However the eosinophil count f nasal mucus beetween these groups after intervention showed no significant diference (p=0.375). In contras, the quality of life score between these grups after the intervention is statistically significant (p=0.046).Conclusion : The Zinc supplementation decreases the eosinophil count of nasal mucous before the intervention. However, there is no significant difference between the two groups after the intervention. The Zinc supplementation showed an increase in the quality of life in moderate to severe persistent allergic rhinitis patient.

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