ORIGINAL ARTICLE

Correlation of Interleukin-6 serum level and surgical site infection in post major surgery patient

Supomo Supomo

Supomo Supomo
Thoracic and Cardiovascular Surgery Division, Department of Surgery, Dr. Sardjito General Hospital, Faculty of Medicine, Universitas Gadjah Mada. Email: supomo.tkv@mail.ugm.ac.id
Online First: October 03, 2018 | Cite this Article
Supomo, S. 2018. Correlation of Interleukin-6 serum level and surgical site infection in post major surgery patient. Bali Medical Journal 8(1): 18-20. DOI:10.15562/bmj.v8i1.1004


Background: Surgical site infections (SSI) are a common surgery complication which early diagnosis is important to initiate an adequate therapy promptly. Objective: To explore the possibility of using serum Interleukin-6 (IL-6) in patients who had major surgery as a biomarker to predict SSI. Patients and Methods: From October to December 2011, 50 patients who underwent major surgery in Sardjito General Hospital Department of Surgery, Yogyakarta were followed up for their IL-6 serum on the third day following the surgery. The patients were also assessed whether they contracted SSI or not. Results: SSI was present in sixteen out of 45 patients (35.6%). The serum IL-6 level was higher in the group which SSI present where 84.5% of the sample was higher than 10 pg/ml. The Chi-square test showed SSI is related to abnormal IL-6 level (OR 4.941, p<0.05). Conclusion: Post-operative IL-6 higher than normal serum level was associated with SSI. The result indicates that IL-6 serum level may be a useful predictor of the occurrence of SSI in patients who underwent major surgery.

 

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