ORIGINAL ARTICLE

Association of Helicobacter pylori and Left Ventricular Ejection Fraction in Patients with Acute Myocardial Infarction

Starry Homenta Rampengan , Jimmy Posangi, Trina Ekawati Tallei, Suzanna Immanuel, Julius Lolombulan, Joedo Prihartono

Starry Homenta Rampengan
Departement of Cardiology and Vascular Medicine, Faculty of Medicine, University Sam Ratulangi, Manado. Email: starry8888@yahoo.com

Jimmy Posangi
Departement of Pharmacology, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

Trina Ekawati Tallei
Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia

Suzanna Immanuel
Departement of Clinical Pathology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

Julius Lolombulan
Department of Mathematics and Natural Sciences Faculty, State University of Manado, Indonesia

Joedo Prihartono
Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Online First: November 29, 2016 | Cite this Article
Rampengan, S., Posangi, J., Tallei, T., Immanuel, S., Lolombulan, J., Prihartono, J. 2016. Association of Helicobacter pylori and Left Ventricular Ejection Fraction in Patients with Acute Myocardial Infarction. Bali Medical Journal 5(3): 556-561. DOI:10.15562/bmj.v5i3.353


Background: Helicobacter pylori (H. pylori) causes continuous inflammation of the stomach. It is suspected that H. pylori infection is associated with an inflammatory response in acute myocardial infarction (AMI). This research was aimed at analyzing the association of Helicobacter pylori infection and the degree of reduction in left ventricular ejection fraction (LVEF) in patients with AMI, the number of coronary heart disease (CHD) risk factors with H. pylori on AMI incident, and association of type of AMI and H. pylori on AMI incident. Method: This is a prospective cohort study with observational-analytic method in AMI patients at ICCU of Prof. Dr. R. D. Kandou General Hospital Manado in 2015-2016. Data retrieval was done by filling out questionnaires, examination of blood samples, serology test to examine the presence of H. pylori, and echocardiography examination in patients with AMI. Results: Statistical analysis showed no significant association between H. pylori with the degree of reduction in LVEF in AMI patients (p=0.713), and the number of CHD risk factors (p=0.087). There was a significant association between H. pylori and types of IMA (p=0.017). There were more ST-Elevation Myocardial Infarction (STEMI) patients infected with H. pylori. Conclusion: There is no significant association between H. pylori infection and the degree of reduction in LVEF in AMI patients, and also the number of CHD risk factors. However, there is a significant association between AMI type and H. pylori on AMI, to wit there are more STEMI patients with H. pylori infections.

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