ORIGINAL ARTICLE

Examining The Effect of Iodized Contrast Agent of Coronary Heart Angiography in People Without Thyroid Gland Disorders

Marzieh Moradirizi, Mahmoud Mirhoseini , Arsalan Khaledifar, Abdolmajid Taheri, Abbas Rezaee

Marzieh Moradirizi
Shahrekord University of Medical Sciences, Shahrekord-Iran

Mahmoud Mirhoseini
Department of Endocrinology,Shahrekord University of Medical Sciences, Shahrekord-Iran. Email: Mirhoseini@skums.ac.ir

Arsalan Khaledifar
Cardiovascular Research Laboratory,Shahrekord University of Medical Sciences,Shahrekord-Iran

Abdolmajid Taheri
Department of Radiology,Shahrekord University of Medical Sciences,Shahrekord-Iran

Abbas Rezaee
Shahrekord University of Medical Sciences,Shahrekord-Iran
Online First: October 07, 2016 | Cite this Article
Moradirizi, M., Mirhoseini, M., Khaledifar, A., Taheri, A., Rezaee, A. 2016. Examining The Effect of Iodized Contrast Agent of Coronary Heart Angiography in People Without Thyroid Gland Disorders. Bali Medical Journal 5(3): 457-462. DOI:10.15562/bmj.v5i3.318


Background: Iodine has a significant effect on thyroid function. A dose of 200 ml of contrast agent contains 35 mg/ml equivalent of 7000 Mg of free iodine and 45 times of the recommended daily dose. This high dose can cause a sudden loss of iodine adjustment, thyroid hormone synthesis, and impair the function of the thyroid gland. Methods: This study is a cross-sectional study (descriptive - analytical) conducted in census method on 70 patients including 40 men and 30 women referring to Hajar medical education hospital for coronary angiography. Thyroid function tests were given before and after receiving the contrast agent angiography and the changes were finally analyzed. Results: In this study, after receiving iodinated contrast agent, 8 out of 70 cases studied significantly suffered subclinical hypothyroidism and no one suffered overt hypothyroidism or hypothyroidism. In terms of distribution based on age, there was no significant difference between different age groups in the intensity of hypothyroidism. In terms of gender distribution, from among 70 cases studied, 40 were men, of whom three suffered subclinical hypothyroidism. Thirty of the subjects were women, of whom five persons suffered subclinical hypothyroidism. Conclusion: The results show that angiography contrast agent can have effects on the thyroid function of the people with euthyroid, so that out of the 70 patients studied, all of whom were euthyroid, eight patients suffered subclinical hypothyroidism. (p=0.018). Moreover, the age and sex of the participants had no effects on thyroid disorder after receiving angiography contrast agent (P=0.5).

References

Toprak O, Cirit M, Bayata S, Yeşil M. Review of the radiocontrast nephropathy risk profiles and risk stratification. AnadoluKardiyolDerg. 2004; 4: 331-5.

Habeb M, Ağaç MT, Aliyev F, Pehlivanoğlu, ngen Z. Contrast media-induced nephropathy: clinical burden and current attemptsfor prevention. AnadoluKardiyolDerg. 2005; 5:124-9.

Katzberg RW, Haller C. Contrast-induced nephrotoxicity; clinicall and scape. Kidney Int. 2006; Suppl(4): S3-S7.

Horster FA, Klusmann G &Wildmeister W. TheKropf: An endemic disease in the Federal RepublicGerman. Dtsch Med Wochenschr.1975; 100: 8-9

Martins MC, Lima N, Knobel M, Medeiros-Neto G. Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in endemic goiter area: a 5 year follow-up. J Endocrinol Invest. 1989; 12: 239- 44.

Roti E, Uberti ED. Iodine excess and hyperthyroidism. Thyroid.2001; 11: 493.

Vagenakis AG, Wang C-A, Burger A, Maloof F, Bravermann LE. Iodine-induced thyrotoxicosis in Boston.N Engl J Med. 1972; 11: 523–7.

Savoie JC, Massin JP, Thomopoulos P. Iodine-induced thyrotoxicosis in apparently normal thyroid glands. JClinEndocrinolMetab.1975; 41: 685–91.

Vagenakis AG, Downs P, Braverman LE, Burger A, Ingbar SH.Control of thyroid hormone secretion in normal subjects receiving iodides. J Clin Invest. 1973; 52: 528-32.

Hintze G, Blombach O, Fink H, Burkhardt U, Kobberling J. Risk of iodine- induced thyrotoxicosis after coronary angiography: an investigationin 788 unselected subjects. J Endocrinol. 1999; 140: 264-7.

Stanbury JB, Ermans AE, Bourdoux P. Iodine-induced hyperthyroidism: occurrence and epidemiology. Thyroid; 1998; 8: 83.

Skare S, Frey HM. Iodine induced thyrotoxicosis in apparently normal thyroid glands. ActaEndocrinol (Copenh). 1980; 94: 332- 6.

Burgi H. Iodine excess.Best Pract Res ClinEndocrinolMetab. 2010; 24: 107.

Braverman LE. Iodine and the thyroid: 33 years of study. Thyroid.1994; 4: 351.

Roti E, Minelli R, Gardini E. Impaired intrathyroidal iodine organification and iodineinduced hypothyroidism in euthyroid women with a previous episode of postpartum thyroiditis. J ClinEndocrinolMetab.1991; 73(5): 958-63.

Clark OH, Cavalieri RR, Moser C, Ingbar SH. Iodide-induced hypothyroidism in patientsafter thyroid resection.Eur J Clin Invest. 1990; 20(6): 573- 80.

Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis AG. Iodine-Inducedhypothyroidism.Thyroid.2001; 11(5): 501-10.

Sato K, Okamura K, Hirata. Immunological and chemical types of reversible hypothyroidism; clinical characteristics and long-term prognosis.ClinEndocrinol (Oxf). 1996; 45(5): 519-28.

Sato K, Ohmori T, Shiratori K.Povidone iodine-induced overt hypothyroidism in a patient with prolonged habitual gargling: urinary excretion of iodine after gargling in normal subjects. Intern Med. 2007; 46(7): 391-5.

Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF,Cobin RH, Franklyn JA, Hershman JM, BurmanKD, Denke MA, Gorman C, Cooper RS, Weissman NJ Subclinical thyroid disease: scientific reviewand guidelines for diagnosis and management. JAMA. 2004; 291(2): 228–38.

Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP, et al. Subclinical hypothyroidism and therisk of coronary heart disease and mortality. JAMA. 2010; 304(12): 1365–74

Razvi S, Weaver JU, Vanderpump MP, Pearce SH. The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. J ClinEndocrinolMetab.2010; 95(4): 1734–40.

Gencer B, Collet TH, Virgini V, Bauer DC, Gussekloo J, Cappola AR, et al. Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from six prospective cohorts. Circulation. 2012;126(9): 1040–9.

McQuade C, Skugor M, Brennan DM, Hoar B, Stevenson C, Hoogwerf BJ. Hypothyroidism and moderate subclinical hypothyroidism are associated with increased all-cause mortality independent of coronary heart disease risk factors: a PreCIS database study. Thyroid.2011; 21(8): 837–43.

Ochs N, Auer R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J, Rodondi N. Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med. 2008; 148(11): 832–45.

Moayyed M ,Zamani J. The effect of coronary angiography on thyroid function. Iranian Journal of Endocrinology and Metabolism.1999; 140(3): 263-7.

Martin FI, Tress BW, Colman PG, Deam DR. Iodine induced hyperthyroidism due to nonionic contrast radiography in the elderly. Am J Med.1993; 95(1): 78-82.

Hintze G, Blombach O, Fink H, Burkhardt U, Kobberling J. Risk of iodine-induced thyrotoxicosis after coronary angiography: an investigation in 788 unselected subjects. Eur J Endocrinol. 1999; 140: 264-9.

Conn JJ, Sebastian MJ, Deam D, Tam M, Martin Fl. A prospective study of the effect of nonionic contrast media on thyroid function.Thyroid. 1996; 6(2): 107-10.

Rahimi M. Coronary angiography contrast agent effect on thyroid function. J Behbood.2006; 1(9): 37-43

Özkan S, Oysu AS, Kayata K. Thyroid functions after contrast agent administration for coronary angiography. AnadoluKardiyolDerg. 2013; 13(4): 363–9.


No Supplementary Material available for this article.
Article Views      : 0
PDF Downloads : 0