ORIGINAL ARTICLE

Comparison of Endometrial Receptivity Between Agonist and Antagonist Protocol in Mice Uterus

AAN Anantasika , IBM Kartha, K Suryanegara, W Tunas

AAN Anantasika
Fertility and Reproductive Endocrinology Division, Department of obstetric and gynaecology Medical Faculty of Udayana University, Sanglah Hospital Denpasar. Email: supad9@yahoo.co.id

IBM Kartha
Resident of Fertility and Reproductive Endocrinology Division, Department of obstetric and gynaecology Medical Faculty of Udayana University, Sanglah Hospital Denpasar

K Suryanegara
Fertility and Reproductive Endocrinology Division, Department of obstetric and gynaecology Medical Faculty of Udayana University, Sanglah Hospital Denpasar

W Tunas
Department of Public Health, Dyana Pura University
Online First: October 05, 2016 | Cite this Article
Anantasika, A., Kartha, I., Suryanegara, K., Tunas, W. 2016. Comparison of Endometrial Receptivity Between Agonist and Antagonist Protocol in Mice Uterus. Bali Medical Journal 5(3): 449-452. DOI:10.15562/bmj.v5i3.316


Background: The implantation rate of IVF remains low due to the adverse effect of ovarian stimulation on endometrial receptivity.  Integrin β3 is the best known marker for endometrial receptivity evaluation. In this study,  the impact of antagonist and agonist protocol on the expression of integrin β during implantation window was investigated. Methods: Two ovarian stimulation protocols were used, involving FSH plus GnRH agonist and FSH plus GnRH antagonist. Uterus sample were collected 48 hr after ovarian stimulation and the expression of integrin β3 detected by immunohistochemistry. Results: The GnRH antagonist treated mice showed significantly lower integrin β3 expression in endometrium during window of implantation than GnRH agonist treated mice. Conclusions: Antagonist protocol has more adverse impact on endometrial receptivity of mice uterus than agonist protocol

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