Brain alteration in chronic pain and the relationship with pain score

Endang Mutiawati , Syahrul Syahrul, Nasrul Musadir

Endang Mutiawati
Pain and Headache Division, Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala/dr. Zainoel Abidin General Hospital, Banda Aceh-Indonesia. Email:

Syahrul Syahrul
Pain and Headache Division, Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala/dr. Zainoel Abidin General Hospital, Banda Aceh-Indonesia

Nasrul Musadir
Pain and Headache Division, Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala/dr. Zainoel Abidin General Hospital, Banda Aceh-Indonesia
Online First: August 01, 2020 | Cite this Article
Mutiawati, E., Syahrul, S., Musadir, N. 2020. Brain alteration in chronic pain and the relationship with pain score. Bali Medical Journal 9(2): 461-465. DOI:10.15562/bmj.v9i2.1809

Brain volume alteration in chronic pain has been studied in many studies. Most of the reviews were reported that the brain volume decrease in chronic pain, although there were some studies reported that the brain volume increased. The alteration mechanism of brain volume was certain unknown, maybe it caused by nerve hyperactivity in the pain pathway, from nociceptor to post-central gyrus. The alteration of substantia grisea volume decreased is interested to know, which it is occurring in the location of the pain pathway of substantia grisea in the brain. This mechanism was one of the body’s ways to reduce the pain score, which then it makes the painless.


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