ORIGINAL ARTICLE

Prevalence of ABO, RhD and other clinically significant Blood Group Antigens among blood donors at tertiary care center, Gwalior

Shelendra Sharma, dharmesh chandra sharma , Sunita Rai, Anita Arya, Reena Jain, Dilpreet Kaur, Bharat Jain

Shelendra Sharma
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India

dharmesh chandra sharma
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India. Email: sharmadrdharmesh@gmail.com

Sunita Rai
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India

Anita Arya
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India

Reena Jain
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India

Dilpreet Kaur
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India

Bharat Jain
Blood Bank, Department of Pathology, G. R. Medical College and J A Hospital Gwalior India
Online First: August 01, 2020 | Cite this Article
Sharma, S., sharma, d., Rai, S., Arya, A., Jain, R., Kaur, D., Jain, B. 2020. Prevalence of ABO, RhD and other clinically significant Blood Group Antigens among blood donors at tertiary care center, Gwalior. Bali Medical Journal 9(2): 437-443. DOI:10.15562/bmj.v9i2.1779


Background: Among all blood group systems and antigens, ABO and D antigens of the Rh blood group system are of primary importance, hence included in routine blood grouping and transfusion. Other blood group systems and antigens that are important in multiparous women, multi-transfused patients and hemolytic disease of newborn are Kell, Rh, Duffy, and Kidd.

Aims and Objectives:  To know the pattern of ABO, RhD and other clinically significant major antigens of Rh, Kell, Duffy and Kidd blood group systems as well as evaluation  of phenotypes, genotypes and gene frequency of related antigens among blood donors in Gwalior region.

Materials and methods:  A prospective study was carried out at the Blood Bank from July 2017 to June 2019. During the study period 48500 blood donors were included for ABO and RhD grouping, Out of them 1000 randomly selected donor samples were processed for complete Rh, Kell, Duffy and Kidd blood grouping.

Result:  ABO group pattern was; A - 22.56%, B -  36.52%, AB - 9.8% and O -31.12 %,  while RhD status was RhD+ 90.99% and RhD- 9.01% .  Prevalence of  Rh phenotypes was DCCee 43%, DCcee 33%, DCcEe 10%, dccee  6.5%, DccEe  4.5%, Dccee  1%, DCCEe  0.3% and dccEe 0.2%. Kell phenotype was K-k+ 95.5%, K+k+ 4.5%, while K+ k- and K- k- phenotypes were not encountered in this study. Duffy phenotypes were Fya+ Fyb+ 47.5%, Fya+ Fyb- 35%, Fya- Fyb+17% and Fya- Fyb- 0.5%. Kidd phenotype was Jka+ Jkb- 44.5 %, Jka- Jkb- 26.5%, Jka+ Jkb+ 18% and Jka- Jkb+ 11%.

Conclusion: Present study is helpful in the transfusion management of multiparous women and multi-transfused patients. Extended blood grouping is the need of future to ensure safe blood transfusion practices.

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