ORIGINAL ARTICLE

A cross-sectional study: The correlation of pro-angiogenic factors expression level and epithelial ovarian cancer staging

Teguh Prakosa , Ambar Mudigdo, Bambang Purwanto, Brian Wasita, Risya Cilmiaty, Vitri Widianingsih

Teguh Prakosa
Department of Obstetrics and Gynecology Dr. Moewardi General Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia. Email: teguhprakosa_spog@yahoo.com

Ambar Mudigdo
Department of Anatomical Pathology Dr. Moewardi General Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

Bambang Purwanto
Department of Internal Medicine Dr. Moewardi General Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

Brian Wasita
Department of Internal Medicine Dr. Moewardi General Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

Risya Cilmiaty
Department of Dental and Oral Medicine Dr. Moewardi General Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

Vitri Widianingsih
Department of Public Health, Dr. Moewardi General Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Online First: April 01, 2020 | Cite this Article
Prakosa, T., Mudigdo, A., Purwanto, B., Wasita, B., Cilmiaty, R., Widianingsih, V. 2020. A cross-sectional study: The correlation of pro-angiogenic factors expression level and epithelial ovarian cancer staging. Bali Medical Journal 9(1): 125-128. DOI:10.15562/bmj.v9i1.1605


Background: Cancer is caused by uncontrolled cell growth and angiogenesis as a vital component in tumor growth and metastasis. Angiogenesis provides nutrients needed by cancer cells in order to grow. Angiogenesis is triggered by pro-angiogenic mediators and overexpression of these mediators have been associated with malignant phenotype of ovarian cancer. It is thought that the more advanced tumors have higher tumor cell survival, proliferation, invasion, and angiogenesis, so that it will show higher expression of pro-angiogenesis mediators.

Objective: To examine the differences in nerve growth factor (NGF), tyrosin kinase receptor A (TrkA), and vascular endothelial growth factor (VEGF) expression level in different stages of epithelial ovarian cancer.

Patients and methods: This is a retrospective cross-sectional study conducted from June to August 2019 in the Department of Obstetrics and Gynecology in association with the Department of Anatomic Pathology of Dr. Moewardi General Hospital, Surakarta, Indonesia. The staging of the epithelial ovarian cancer was determined using the FIGO 2014 staging system. NGF, TrkA, and VEGF expression level were determined using immunohistochemical examination.

Results:The samples were 53 formalin-fixed, paraffin-embedded ovary, its adnexa, uterus, and lymph nodes tissue blocks of epithelial ovarian cancer patients. There are statistically significant differences in the proportion of NGF, TrkA, and VEGF level of expression in different stages of epithelial ovarian cancer (p<0.05).

Conclusion: There are statistically significant differences in NGF, TrkA, and VEGF level of expression in different stages of epithelial ovarian cancer.

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