ORIGINAL ARTICLE

Correlation between the level of interleukin-6 serum and blood peripheral leukocyte in patients with severe traumatic brain injury

Edwin Calvin Bangun , Eko Prasetyo, Maximillian Christian Oley

Edwin Calvin Bangun
Surgery resident, Faculty of Medicine, Universitas Sam Ratulangi, Manado, Indonesia. Email: nivlacniwde@yahoo.com

Eko Prasetyo
Neuro Surgery Division, Department of Surgery, Universitas Sam Ratulangi/Prof. dr. R.D. Kandou General Hospital Manado.

Maximillian Christian Oley
Neuro Surgery Division, Department of Surgery, Universitas Sam Ratulangi/Prof. dr. R.D. Kandou General Hospital Manado.
Online First: December 01, 2019 | Cite this Article
Bangun, E., Prasetyo, E., Oley, M. 2019. Correlation between the level of interleukin-6 serum and blood peripheral leukocyte in patients with severe traumatic brain injury. Bali Medical Journal 8(3): SS784-S787. DOI:10.15562/bmj.v8i3.1548


Background: Increased level of interleukin 6 (IL-6) in patients with severe traumatic brain injury (TBI) has been documented, yet studies of its ability to predict the outcome based on the Leukocyte is limited and lacks clarity. This study aims to evaluate the relationship between serum level of IL 6 and Leukocyte among patients with severe TBI.

Methods: Twenty patients admitted consecutively to the emergency room (ER) with severe TBI were included in this observational, cross-sectional, single-centre study. Venous blood sample for IL 6 and leukocyte was performed less than 24 hours of trauma in the Intensive Care Unit.  Age and gender were also recorded. Variable selection was run in stepwise forward fashion. Correlational odds models were conducted to assess how change in Leukocyte is related to levels of IL 6. Data were analysed using SPSS version 17 for Windows.

Results: The average age of respondents was 32.45±10.71 years old and mostly males (85%). The Glasgow Coma Scale (GCS) was predominant in score 8 (45%). The mean value of IL-6 was 22.00±4.66 pg/ml and 22.53±8.11 x 103 in leucocyte. The weak insignificant correlation was found between IL-6 and blood peripheral leucocyte using Pearson Correlation test (r = - 0.290; p = 0.108)

Conclusion: The recent findings suggest that there is no correlation between IL 6 levels and Leukocyte in patients with severe TBI.

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